نتایج جستجو برای: hypermethylation

تعداد نتایج: 5378  

Journal: :American Journal of Respiratory Cell and Molecular Biology 2008

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Yutaka Suehiro Chi Wai Wong Lucian R Chirieac Yutaka Kondo Lanlan Shen C Renee Webb Yee Wai Chan Annie S Y Chan Tsun Leung Chan Tsung-Teh Wu Asif Rashid Yuichiro Hamanaka Yuji Hinoda Rhonda L Shannon Xuemei Wang Jeffrey Morris Jean-Pierre J Issa Siu Tsan Yuen Suet Yi Leung Stanley R Hamilton

PURPOSE Early events in colorectal tumorigenesis include mutation of the adenomatous polyposis coli (APC) gene and epigenetic hypermethylation with transcriptional silencing of the O(6)-methylguanine DNA methyltransferase (MGMT), human mut L homologue 1 (hMLH1), and P16/CDKN2A genes. Epigenetic alterations affect genetic events: Loss of MGMT via hypermethylation reportedly predisposes to guanin...

2009
Toshinori Hinoue Daniel J. Weisenberger Fei Pan Mihaela Campan Myungjin Kim Joanne Young Vicki L. Whitehall Barbara A. Leggett Peter W. Laird

A CpG island methylator phenotype (CIMP) is displayed by a distinct subset of colorectal cancers with a high frequency of DNA hypermethylation in a specific group of CpG islands. Recent studies have shown that an activating mutation of BRAF (BRAF(V600E)) is tightly associated with CIMP, raising the question of whether BRAF(V600E) plays a causal role in the development of CIMP or whether CIMP pr...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Wenyue Sun David Zaboli Hao Wang Yan Liu Demetri Arnaoutakis Tanbir Khan Zubair Khan Wayne M Koch Joseph A Califano

PURPOSE To validate a panel of methylation-based salivary rinse biomarkers (P16, CCNA1, DCC, TIMP3, MGMT, DAPK, and MINT31) previously shown to be independently associated with poor overall survival and local recurrence in a larger, separate cohort of patients with head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN One hundred ninety-seven patients were included. All pretreatm...

2015
Yunshu Su Xiaoli Wang Jun Li Junming Xu Lijun Xu

FHIT is a bona fide tumor-suppressor gene and its loss contributes to tumorigenesis of epithelial cancers including breast cancer (BC). However, the association and clinicopathological significance between FHIT promoter hypermethylation and BC remains unclear. The purpose of this study is to conduct a meta-analysis and literature review to investigate the clinicopathological significance of FHI...

2002
NANCY Y. ASAAD NADIA M. MOKHTAR

There are several molecular pathways of colorectal cancer. At least four separate pathways of colorectal cancer exist: (A) adenomatous polyposis coli pathway in which B cateni-T cell factor-MYC factors are implicated (APC-B catenin-Tcf-MYC) in adenoma carcinoma sequence, (B) hereditary non-polyposis colorectal cancer pathway (HNPCC) characterized by loss of DNA mismatch repair by inherited or a...

2013
Zhe Jin Liang Wang Yuan Zhang Yulan Cheng Yan Gao Xianling Feng Ming Dong Ziyi Cao Si Chen Huimin Yu Zhenfu Zhao Xiaojing Zhang Jie Liu Yuriko Mori Xinmin Fan Stephen J. Meltzer

MAL promoter hypermethylation was examined in 260 human esophageal specimens using real-time quantitative methylation-specific PCR (qMSP). MAL hypermethylation showed highly discriminative ROC curve profiles which clearly distinguished esophageal adenocarcinomas (EAC) from both esophageal squamous cell carcinomas (ESCC) and normal esophagus (NE). Both MAL methylation frequency and normalized me...

2014
RUPNINDER SANDHU ASHLEY G. RIVENBARK RANDI M. MACKLER CHAD A. LIVASY WILLIAM B. COLEMAN

Basal-like breast cancers frequently express aberrant DNA hypermethylation associated with concurrent silencing of specific genes secondary to DNMT3b overexpression and DNMT hyperactivity. DNMT3b is known to be post-transcriptionally regulated by microRNAs. The objective of the current study was to determine the role of microRNA dysregulation in the molecular mechanism governing DNMT3b overexpr...

Journal: :Cancer research 2008
Angela H Ting Hiromu Suzuki Leslie Cope Kornel E Schuebel Byron H Lee Minoru Toyota Kohzoh Imai Yasuhisa Shinomura Takashi Tokino Stephen B Baylin

Promoter hypermethylation is a prevalent phenomenon, found in virtually all cancer types studied thus far, and accounts for tumor suppressor gene silencing in the absence of genetic mutations. The mechanism behind the establishment and maintenance of such aberrant hypermethylation has been under intense study. Here, we have uncovered a link between aberrant gene silencing associated with promot...

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