Background: Hyperlipidemia is a major risk factor for cardiovascular disease (CVD), which is the number one cause of mortality and morbidity in Western civilization. Objective: We assessed the effects of a two-month program using a combination of nutraceutical agents known to improve lipid profiles in hyperlipidemic individuals. Design: In an open-label thirty participants study, hyperlipidemic...

The present study was undertaken to evaluate the efficacy of freeze dried extract of Clerodendron glandulosum Coleb., Verbenaceae, leaves (FECG) on alteration in lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in ...

OBJECTIVE The arterial retention of apolipoprotein (apo) B100- and apoB48-containing lipoproteins was simultaneously determined in a rabbit model of human hypercholesterolemia using 3D confocal microscopy. METHODS AND RESULTS Lipoproteins containing apoB100 (LDL) and apoB48 (chylomicron remnants) were differentially conjugated with fluorophores and simultaneously perfused at equivalent concen...

BACKGROUND A 37 year-old man presented to the emergency department complaining of six hour diffuse abdominal pain accompanied by persistent vomiting. CASE REPORT The patient had a heavy meal a few hours before. There were no signs of peritonitis. Routine laboratory examinations revealed leukocytosis, hyperglycemia and hyperamylasemia (serum amylase: 380 mg/dl, urinary amylase: 1150 mg/dl). ...

To evaluate the antihyperlipidemic activities of Orengedokuto (OT) and Daio-Orengedokuto (DOT), the inhibitory effects of these polyprescriptions on HMG-CoA reductase and pancreatic lipase and on the rat hyperlipidemic model induced by Triton WR-1339 were measured. OT potently inhibited HMG-CoA reductase but did not inhibit lipase. Among their ingredients, Coptidis Rhizoma was the most potent i...

Cucumis melo Linn. (Cucurbitaceae) fruits have been used, traditionally, for the treatment of various disorders of heart as Cardioprotective and antiobesity. The aim of the present study was to investigate the possible anti-hyperlipidemic activity of Cucumis melo fruit peel extract in triton induced hyperlipidemia in rats. Chloroform, Methanolic and aqueous extracts of were administered to the ...