Nausea and vomiting of pregnancy is a common condition with prevalence rates for nausea of 50–80% and for vomiting and retching of 50% (5). An estimated 50% of pregnant women have nausea and vomiting, 25% have nausea only, and 25% are unaffected (6, 7). Recurrence of nausea and vomiting of pregnancy with subsequent pregnancies ranges from 15.2% to 81% (8). One study has attempted to categorize ...

OBJECTIVE To compare ondansetron with metoclopramide in the treatment of hyperemesis gravidarum. METHODS We enrolled 160 women with hyperemesis gravidarum in a double-blind randomized trial. Participants were randomized to intravenous 4 mg ondansetron or 10 mg metoclopramide every 8 hours for 24 hours. Participants kept an emesis diary for 24 hours; at 24 hours, they expressed their well-bein...