swine flue is a highly contagious acute respiratory disease caused by a subtype of influenza a virus. herein we present three patients with h1n1 infection complicated with pulmonary thromboembolism. the patients had chest pain and unexplained dyspnea. imaging studies showed bilateral hilar predominance. computed tomographic angiography confirmed bilateral thromboembolism (an unusual presentatio...

Background: The numbers of individuals age 50 and over who maintain active lifestyles is growing. Many of these individuals travel to or live at, higher altitudes, to pursue outdoor activities or travel to higher altitudes for business. The use of anticoagulant therapy has continued to increase over the past two decades among individuals 50 and over. Warfarin is effective but requires a narrow ...

Traumatic brain injury (TBI) is associated with coagulopathy, although it often lacks 2 key risk factors: severe bleeding and significant fluid resuscitation associated with hemorrhagic shock. The pathogenesis of TBI-associated coagulopathy remains poorly understood. We tested the hypothesis that brain-derived microparticles (BDMPs) released from an injured brain induce a hypercoagulable state ...

Introduction An early activation of coagulation and fibrinolysis occurs during sepsis and results in a marked increase of thrombin and fibrin formation, leading to the syndrome of disseminated intravascular coagulation (DIC). DIC is a strong predictor of death and multiple organ failure in patients with septic shock [1]. Obesity has been demonstrated to be a hypercoagulable [2] and hypofibrinol...

Two cases of women who developed internal jugular vein (IJV) thrombosis associated with ovarian hyperstimulation syndrome (OHSS) are reported in this article. There are 27 cases of IJV thrombosis associated with in vitro fertilisation (IVF) reported in the literature, and in 78% of cases, this outcome was following OHSS. The hypercoagulable state of OHSS increases the risk of venous thromboembo...

Chicken pox (Varicella) infection is generally present in children and caused by Varicella Zoster Virus (VZV). There are quite a number of case reports of hypercoagulable state leading to deep venous thrombosis (DVT) and other thromboembolic sequelae following varicella induced auto antibodies to natural anticoagulants in children. But such a clinical entity is rarely seen in adults. Here we re...

PAH is defined as mean pulmonary pressure >25 mmHg at rest and >30 mmHg with exercise. The pathogenesis of PAH in systemic sclerosis involves endothelial cell injury. With endothelial cell dysfunction, there is reduced nitrous oxide and prostaglandin production, and increased endothelin-1 production. Vascular wall remodeling then follows with intimal and smooth muscle proliferation. Luminal nar...

Multiple myeloma is considered a hypercoagulable state due to several mechanisms such as the increased IL-6 and immunoglobulins production, the defective fibrinolytic mechanism, and the acquired resistance to activated protein C that are involved in the pathogenesis and clinical futures of the disease. We describe a case of a female patient who presented to the hospital with pulmonary embolism ...

• Large vessel ischemic strokes uncommonly account for new focal deficits in patients with primary brain tumors, mimicking intratumoral hemorrhage, tumor progression, or Todd paralysis. • Stroke occurring in the context of a primary brain tumor is usually a postoperative complication, a late complication of radiation therapy, or embolic due to a hypercoagulable state induced by the tumor. • Rar...

Pregnancy is a hypercoagulable state and venous thromboembolism 10 times more common in pregnancy leading cause of maternal mortality. Anaesthesia itself challenging. Pulmonary its management further ads to that challenge. Plan anaesthesia has be decided weighing the risk benefit ratio. We hereby report successful administration subarachnoid block non-obese primigravida with diagnosed acute PTE...