In this research, the synthesis of 1,3,5,7-tetrahydroxy-9,10-anthraquinone (1) and two anthrone derivatives, 1,3,5,7-tetrahydroxy-10H-anthracene-9-one (2) 1-hydroxy-3,5,7,9-tetramethoxyanthracene (3) has been done. Compound 1 was synthesized by a symmetrical condensation reaction 3,5-dihydroxybenzoic acid in concentrated sulfuric acid. Reduction carbonyl group compound with SnCl2/HCl-HOAc affor...

2.7. Redox Deprotections 221 3. Thiol Protecting Groups 223 4. Carboxy Protecting Groups 223 4.1. Protection 224 4.2. Deprotection 226 5. Carbonyl Protecting Groups 227 5.1. Acetals 227 5.1.1. Protection 227 5.1.2. Deprotection 231 5.2. Dithioacetals 233 5.2.1. Protection 233 5.2.2. Deprotection 235 5.3. 1,3-Oxathiolanes 237 5.4. 1,1-Diacetates (Acylals) 238 5.4.1. Protection 238 5.4.2. Deprote...

BACKGROUND Since the enactment of the Affordable Care Act (ACA), the rate of uninsured in the United States has declined significantly. However, not all legal residents have benefited equally. As part of a community-based participatory research (CBPR) partnership with the Marshallese community, an interpretative policy analysis research project was conducted to document Marshallese Compact of F...

Introduction: Sun protection plays a role in skin cancer prevention, but there are concerns it increases the risk of vitamin D (VD) deficiency. Here, we examine sun dependent differences VD deficiency among racial groups. Methods: Serum 25(OH)D levels and protective behaviors staying shade, wearing long sleeves, using sunscreen) questionnaire responses 9143 adults were extracted from US Nationa...

The aim of this pharmacokinetic evaluation was to show the effect of the extra methyl group in simvastatin on esterase hydrolysis between lovastatin and simvastatin in male and female volunteers. This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and simvastatin with its respective active metabolite statin-beta-hydroxy acid obtained from two diff...

The structural motif of α,α-difluoro-substituted carboxyl and carbonyl groups with hydroxy- or amino-substituents at the stereogenic carbon in β-position is found frequently drugs biologically active compounds. A straightforward method for obtaining those targets high enantiomeric purity given by asymmetric difluoro-Reformatsky imino-difluoro-Reformatsky reactions that lead to α,α-difluorinated...