Fe(II)/?-ketoglutarate-dependent dioxygenases (KDOs) catalyze a broad range of selective C–H oxidation reactions. However, the difficult production KDOs in recombinant E. coli strains and their instability purified form have so far limited application preparative biotransformations. Here, we investigated immobilization three (CaKDO, CpKDO, FjKDO) that stereoselective hydroxylation L-lysine side...

Spectrophotometric methods were used to study the reaction of complexation tungsten with derivatives o-hydroxythiophenol (HTPDs) {2-hydroxy-5-chlorothiophenol (HCTP), 2-hydroxy-5- bromothiophenol (HBTP) and 2-hydroxy-5-iodothiophenol (HITP )} in presence aminophenols. Aminophenols 2(N,N-dimethylaminomethyl)-4-chlorophenol (AP1) 2(N,Ndimethylaminomethyl)-4-bromophenol (AP2), 2(N,N-dimethylaminom...

In the title compound, C(27)H(30)O(14)·H(2)O, the hydroxy-phenyl ring makes a dihedral angle of 20.05 (11)° with the chromenone ring system. The crystal structure is stabilized by intra- and inter-molecular O-H⋯O hydrogen bonds. The absolute configuration was assigned on the basis of an analagous structure.

The asymmetric unit of the title compound, C(10)H(9)NO, contains two independent mol-ecules which are linked by a pair of O-H⋯N hydrogen bonds into a hydrogen-bonded dimer.

Five new 1-hydroxy-2-(1-alkyloxymethyl)-9,10-Anthraquinones (9a-e) have been prepared. Selective nitration of 2-methyl-9,10-anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-2-methyl-9,10-anthraquinone in good yield as the key intermediate. Reaction with dimethylsulphate/K2CO3 and subsequen...

Novel 9alpha and 9beta-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9alpha and 9beta-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9beta-hydroxy-dihydro grayanotoxin II was higher t...