In this work, we aim to develop a dual drug delivery system (DDDS) of self-assembled micelles in thermosensitive hydrogel composite to deliver hydrophilic and hydrophobic drugs simultaneously for colorectal peritoneal carcinomatosis (CRPC) therapy. In our previous studies, we found that poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCEC) copolymers with different molecular we...

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untre...

Curcumin is a biopharmaceutical classification system (BCS) class IV substance with many potential therapeutic effects. However, like other BCS active pharmaceutical ingredients, complex formulations are needed to guarantee sufficiently high bioavailability. A not-so-well-known delivery suspoemulsion (SE). SEs emulsions crystalline API in continuous or dispersed phases. This study aimed produce...

Hydrogels' applications are usually limited by their weak mechanical properties. Despite recent great progress in developing tough hydrogels, it is still challenging to achieve high values of , toughness and modulus all together in synthetic hydrogels. In this paper, we designed highly stretchable, tough, yet stiff hydrogel composites via a combination of nanoscale hybrid crosslinking and macro...

Hydrogels of 2-hydroxyethyl methacrylate (HEMA) cross-linked with N,N′-cystaminebis(acrylamide) (CBA) were prepared inside microchannels using an in situ photopolymerization for the study of chemical-responsive microgels. By chemically reducing disulfide bonds with dithiothreitol (DTT), the cross-link density of the hydrogel network decreased, leading to an observable swelling of the hydrogel. ...

A hydrogel intracorneal lens for refractive keratoplasty must have predictable and stable optics when implanted in the corneal stroma. A series of experiments was performed to evaluate the hydrogel hydration stability when in the corneal stromal environment. Hydrogel ICLs of 54%, 63%, 66% and 71% water content showed no loss of hydration (by weight) after one week in the rabbit corneal stroma. ...

We report an all-dry fabrication method of the hybrid structure of pH-responsive hydrogel and carbon nanotube arrays using initiated chemical vapor deposition (iCVD). Vertically aligned carbon nanotube (VACNT) arrays with low site density were coated by a vapor-deposited poly(methacrylic acid-coethylene glycol diacrylate) hydrogel with complete retention of the aligned structure and precise con...

Recent advances in understanding the interaction between electricity and cells/biomolecules have generated great interest in developing biocompatible electrically conductive materials. In this study, we investigated the biocompatibility of a myo-inositol hexakisphosphate gelated polyaniline hydrogel using in vitro and in vivo experiments in a rat model. The polyaniline hydrogel was used to coat...

The development of a simple, easy-to-use, and noninvasive vaccination system is in high demand. For transcutaneous immunization (TCI), we previously reported that a hydrogel patch was an effective TCI device that accelerates antigen penetration through the stratum corneum in mouse and rat models. The present study was performed to characterize the transcutaneous protein delivery induced by the ...