نتایج جستجو برای: hydralazine
تعداد نتایج: 1395 فیلتر نتایج به سال:
We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/liter) or hydralazine (80 mg/liter) or no treatment for six weeks. Body weight inc...
BACKGROUND We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy. METHODS A total of 1050 black patients who had New York Heart Association class III or IV heart failure with dilated ventricles were randomly assigned to receive a f...
BACKGROUND Aberrant DNA methylation and histone deacetylation participate in cancer development and progression; hence, their reversal by inhibitors of DNA methylation and histone deacetylases (HDACs) is at present undergoing clinical testing in cancer therapy. As epigenetic alterations are common to breast cancer, in this proof-of-concept study demethylating hydralazine, plus the HDAC inhibito...
The role of angiotensin II type 2 receptors (AT2Rs) remains a matter of controversy. Its vasodilatory and antitrophic properties are well accepted. Nevertheless, in hypertensive rats, AT2R stimulation induces a vasoconstriction counteracting flow-mediated dilation (FMD). This contraction is reversed by hydralazine. Because FMD is also decreased in aging, another risk factor for cardiovascular d...
Although vasodilator drugs acutely reduce regurgitation and improve cardiac performance in aortic insufficiency, their long-term effects on left ventricular size and function are uncertain. Consequently, we performed a double-blinded, placebo-controlled trial using hydralazine in 80 minimally symptomatic patients who had clinically stable, moderate-to-severe aortic insufficiency. Patients rando...
Several reports have suggested that because isosorbide dinitrate and hydralazine have different and additive haemodynamic effects at rest in patients with chronic heart failure, these agents should be administered in combination. Some studies, however, indicate thay they are effective individually as well. Since most patients with heart failure are symptomatic only with activity, we examined th...
PRECEDING INVESTIGATIONS have shown that administration of hydralazine (1-hydrazinophthalazine) is accompanied by an inerease in cardiac output,1-5 particularly if the decrease in blood pressure subsequent to its administration is not excessive,5 and by increased renal,6 hepatic,4 and coronary7 blood flow. Cerebral blood flow has been reported to be unchanged by hydralazine, even though cerebra...
CHEST, 78: 2, AUGUST, 1980 edema, pseudocyst formation or development of fibrous penpancreatic adhesions may all lead to obstruction of the intestinal lymphatics as they converge into the root of the mesentery in the region of the uncinate process of the pancreas and cause chylous ascites.’ The association of chylous ascites and chylothorax has been documented.’ Intraperitoneal injection of con...
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