Background: The functional longevity of ovarian transplant at present is one of the most challenging questions regarding ovary transplantation. So, we used hyaluronic acid (HA) hydrogel scaffold with combination of VEGF and bFGF for restoration of cyclical ovarian function after ovarian tissue transplantation in a rat model. Materials and Methods: A total of 25 Wistar female rats weighing betwe...

All major glycosaminoglycans except keratan sulphate are found in animal lung and pleura (Wusteman, 1972). Pleural fluids from patients with several pulmonary diseases contain mostly hyaluronic acid (Friman, Hellstrom, Juvani & Riska, 1977). The high concentration of hyaluronic acid in pleural fluid associated with mesothelioma is considered diagnostic of this disease (Havez, Degand, Boersma & ...

A readily available source of pure hyaluronic acid is a necessity in studies involving the ground substance of connective tissue and its relation to diverse spreading factors thought to be important in the pathogenesis of many bacterial diseases. Any objection that contamination with other mucopolysaccharides or protein of hyaluronic acid prepared from mammalian sources is generally likely, unl...

Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelializ...

Scaffolds for cartilage tissue engineering should promote both adequate biomechanical environment and chondrogenic stimulation. Hyaluronic acid (HA) has been used in cartilage engineering for its chondrogenic and chondroprotective properties, nevertheless its mechanical properties are limited. Influence of HA microstructure in chondrocyte response has not been addressed yet. In this work, polyc...

Introduction: The most common biopolymers used to build-up 3D scaffolds for bone and cartilage tissue engineering are chitosan, alginate, cellulose derivatives, hyaluronic acid, chondroitin sulfate, collagen and gelatin. In this study, we propose to evaluate the potential of two new marine exopolysaccharides (HE800 and GY785) that are glycosaminoglycan-like polymers and that can be produced in ...

UNLABELLED AIM.: The aim of this study is to evaluate the capability of Hyaloss™ matrix (Fab - Fidia Advanced Biopolymers - Pd - Italy), a biomaterial based on hyaluronic acid, used as organic scaffold in bone repair in post-extractive defects. MATERIALS AND METHODS 20 post-extractive sockets were selected, with similar size defects in the same patient and in the same hemiarch. Hyaluronic aci...

Ogston & Phelps (1961) found that hyaluronic acid markedly affects the partition of diffusible macromolecules between solutions of the polysaccharide and buffer. The authors explain the phenomenon as a steric exclusion of macromolecular solutes from solutions containing randomly coiled hyaluronic acid chains. From these results one can expect that hyaluronic acid and similar substances would ex...

[Introduction] In cartilage tissue enginnering, a number of studies have shown the importance of selecting the appropriate biomaterials as scaffolds for chondrocyte attachment, for supporting its proliferation and for its synthesis of extra-cellular matrix (ECM). Although a variety of biomaterials, including naturally occurring and synthetic, have been introduced as potential scaffolds for cart...