نتایج جستجو برای: hutchinson gilford syndrome

تعداد نتایج: 623259  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Vaidehi Krishnan Maggie Zi Ying Chow Zimei Wang Le Zhang Baohua Liu Xinguang Liu Zhongjun Zhou

Specific point mutations in lamin A gene have been shown to accelerate aging in humans and mice. Particularly, a de novo mutation at G608G position impairs lamin A processing to produce the mutant protein progerin, which causes the Hutchinson Gilford progeria syndrome. The premature aging phenotype of Hutchinson Gilford progeria syndrome is largely recapitulated in mice deficient for the lamin ...

2015
Jicun Wang-Michelitsch Thomas M. Michelitsch

Hutchinson–Gilford Progeria Syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phenomena of premature aging, the similarity of aging features in the syndromes to that in normal aging is investigated. Although these syndromes have different genetic backgrounds, the patients all have abnormal structu...

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