Background and Aims: Among Human Immunodeficiency Virus (HIV)-infected individuals, Epstein-Barr virus (EBV) and Human Herpesvirus (HHV)-8 could cause significant illness as opportunistic infections. The purpose of the present study was to evaluate the prevalence of EBV and HHV-8 in saliva specimens obtained from HIV-1 infected Iranian individuals under the Highly Active Antiviral Therapy (HAAR...

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8) is a newly identified herpesvirus. KSHV is an important pathogen capable of causing disease that affects all age groups worldwide. KSHV is etiologically associated with all forms of Kaposi's sarcoma (KS), body cavity lymphomas, and multicentric Castleman disease (MCD). The use of highly active antiretroviral therapy (...

Castleman’s disease is a rare non-neoplastic lymphoproliferative disorder of unknown origin. It classified into unicentric or multicentric based on its anatomical distribution. Multicentric can be subdivided according to the presence human herpesvirus-8 (HHV-8) infection. has incidence, and HHV-8-positive even rarer. There are several types natural course for this disease, rapidly progressing t...