conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...

background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the herpesviruses tested in this study. Neither the recombinant alpha nor the recom...

Mutation of the p53 tumor suppressor gene is a recurring event in a variety of human cancers. Wild-type p53 may regulate cell proliferation and has recently been shown to repress transcription from several cellular promoters. We studied the effects of wild-type and mutant human p53 on the human proliferating-cell nuclear antigen promoter and on several viral promoters including the simian virus...

Introduction Although first described in 1872, Kaposi's sarcoma remains a neoplasm of uncertain histiogenesis.' The lesion is considered by some experts to be a vascular neoplasm and by others, a reactive vasoformative condition. Currently, the debate still rages over the precise cell of origin of Kaposi's sarcoma-that is, whether it is of lymphatic or true endothelial cell origin. Clinically, ...

Specific Human Herpes virus-6 (HHV-6) transfer factor (TF) preparation, administered to two chronic fatigue syndrome patients, inhibited the HHV-6 infection. Prior to treatment, both patients exhibited an activated HHV-6 infection. TF treatment significantly improved the clinical manifestations of CFS in one patient who resumed normal duties within weeks, whereas no clinical improvement was obs...

childhood. Ambulatory Child Health. 2000;6:59-66. 4. Kalman CM, Laskin OL. Herpes zoster and zosteriform herpes simplex virus infections in immunocompetent adults. Am J Medic. 1986;81:775-8. 5. Nikkels AF, Nikkels-Tassoudji N, Piérard GE. Revisiting childhood herpes zoster. pediatr dermatol. 2004; 21:18-23. 6. Kakourou T, Theodoridou M, Mostrou G, Syriopoulou V, Papadogeorgaki H, Constantopoulu...

Anal lesions affect up to 34% of patients with Acquired Immunodeficiency Syndrome (AIDS), and are more frequent in males who have sex with males (MSM). The most common anal infection in human immunodeficiency virus (HIV)-positive patients is caused by human papillomavirus (HPV). It is suggested that the appearance of this illness is related to the conversion of HIV into AIDS. Even with the intr...

C ytomegalovirus (CMV) is a ubiquitous herpes virus that, together with human herpesvirus type 6 (HHV-6) and HHV-7, belongs to the β-herpesvirus family. Like other herpes viruses, CMV establishes lifelong latent infections. Infection with CMV is common in all populations, but is infrequently associated with symptomatic illness in healthy hosts. However, CMV is a major cause of morbidity and mor...