نتایج جستجو برای: human epidermal growth factor receptor 2

تعداد نتایج: 5017407  

Journal: :Cancer research 1987
U Rodeck M Herlyn D Herlyn C Molthoff B Atkinson M Varello Z Steplewski H Koprowski

A monoclonal antibody of IgG2a isotype (425) is described that reacts with the epidermal growth factor receptor on human cells of different tissue origins. Monoclonal antibody 425 mediates tumor cytotoxicity in vitro using mouse and human effector cells and suppresses in vivo tumor cell growth of epidermoid (A 431) and colorectal (SW 948) carcinoma-derived cell lines. The tumoricidal effects in...

Journal: :razavi international journal of medicine 0
narges jafarzadeh department of research and education, razavi hospital, mashhad, ir iran hami ashraf department of research and education, razavi hospital, mashhad, ir iran; zakaria idea and innovation support and leading center, tehran, ir iran fahimeh khoshroo department of research and education, razavi hospital, mashhad, ir iran alireza sepehri shamloo student research committee, mashhad university of medical sciences, mashhad, ir iran farzad bidouei department of research and education, razavi hospital, mashhad, ir iran kamran ghaffarzadehgan department of research and education, razavi hospital, mashhad, ir iran; department of research and education, razavi hospital, mashhad, ir iran. tel: +98-5116004594, fax: +98-5116668883

context triple negative breast cancer (tnbc) is a heterogeneous group of diseases that is negative for esterogen receptor (er) progesteron receptor (pr) and human epidermal growth factor receptor 2 (her2). this type of breast cancer is typically high-grade carcinomas, although low-grade tumors occur. the aim of this review is to focus on molecular classification and features, prognostic markers...

2011
Yoriko Yamashita-Kashima Shigeyuki Iijima Keigo Yorozu Koh Furugaki Mitsue Kurasawa Masateru Ohta Kaori Fujimoto-Ouchi

Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab,

2001
Jose A. Fernandez-Pol

A monoclonal antibody to the epidermal growth factor (EGF) receptor of A431 cells, denoted 2Dl-IgM, was generated after fusion of immunized BALB/c mouse spleen cells with SpZ/O-Ag14 myeloma cells, Specific binding of 2D1-IgM to the A431 cell-surface receptor for EGF was demonstrated by indirect immunofluorescence, immunoprecipitation, and immunoblot analysis. Scatchard analysis of lz6I-EGF bi...

2013
Elisavet Paplomata Ruth O’Regan

Management of patients with metastatic hormone receptor-positive breast cancer poses a challenge due to the inevitable development of endocrine resistance. Hormone resistance is associated with a complex interaction of the estrogen receptor with growth factors, transmembrane receptors, and intracellular growth cascades. The PI3K/Akt/mTOR pathway plays a major role in hormone resistance and prol...

2014
Lukas C. Amler Yulei Wang Garret Hampton

Members of the human epidermal growth factor receptor (HER) family—epidermal growth factor receptor (EGFR, HER1), HER2, HER3, and HER4—are transmembrane tyrosine kinase receptors that are important mediators of cell growth, development, and survival. Activation of the HER tyrosine kinases triggers intracellular signaling pathways, including the MAPK and PI3K-Akt pathways (Olayioye et al., 2000)...

2011
Yoriko Yamashita-Kashima Shigeyuki Iijima Keigo Yorozu Koh Furugaki Mitsue Kurasawa Kaori Fujimoto-Ouchi

Purpose: We investigated the antitumor activity of the combination of two different humanized monoclonal human epidermal growth factor receptor (HER) 2 antibodies, pertuzumab and trastuzumab,

Journal: :The Journal of biological chemistry 2008
Akio Soeda Akihito Inagaki Naoki Oka Yuka Ikegame Hitomi Aoki Shin-Ichi Yoshimura Shigeru Nakashima Takahiro Kunisada Toru Iwama

A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as epidermal growth factor, fibroblast growth factor-2, vascular endothelial growth factor, platelet-derived growth factor, and hepatocyte growth factor, are shown to support the proliferation of neural stem cells and also may play key roles in ...

Journal: :P & T : a peer-reviewed journal for formulary management 2015
Jack McCain

Women with hormone receptor-positive, human epidermal growth factor receptor 2- negative breast cancer-the most common subtype-have new options as palbociclib and similar drugs debut. This article outlines the rationale and evidence for their use.

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