Objective: To explore the mechanism of circRNA-vgll3 in osteogenic differentiation human bone marrow mesenchymal stem cells. Methods: BMSCs cells were transfected with circRNA-vgll3, and divided into high-level group, low-level negative control group (circRNA-vgll3 not transfected) according to amount transfection. The proliferation apoptosis osteoblasts each analyzed, alkaline phosphatase (ALP...

We have studied a rapid cultivation method for human mesenchymal stromal cells based on CellGroTM medium and human serum, supplemented with insulin, ascorbic acid, dexamethasone, epidermal growth factor, platelet-derived growth factor BB, macrophage colony-stimulating factor and fibroblast growth factor 2. This study has shown that ...

Biocompatibility and osteoconductivity of porous scaffolds can be improved through coating technique by creating micro- nanostructures on the surfaces. In this study, a biomimetic approach was used to construct bone morphogenetic protein-2 (BMP-2) integrated calcium phosphate (CaP) surface titanium scaffolds. vitro characterizations showed that had mechanical properties comparable those human c...

We describe a patient with insufficient bone regeneration of the tibia after bone transport over an intramedullary nail, in whom union was ultimately achieved after exchange nailing and intramedullary application of rh-bone morphogenetic protein-7 at the site of distraction.

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropathy (DN) has been suggested to be binding and inhibition of BMP-7. However, the precise interacti...

Source and Description of Probe. A 2.2-kb human cDNA clone for bone morphogenetic protein 5 (BMP5) was excised from the clone U2-16 (Celeste et al., 1990).