• Its geographical market definition accounts only for a factor that is no longer relevant and for none of the factors that matter in a competitive market. • Its use of uncommitted-shares registers more market power when the market itself is more competitive and less market power when it is less competitive. Thus it often reads in reverse the impact of the market on the applicant. • It takes no...

In this paper, we present a new formulation of one-stop capacitated hub-and-spoke model as a natural extension of the uncapacitated one-stop model. The model involves arc capacity constraints as well as hub capacity constraints, which enables us to incorporate some practical factors into the model. We also present a branch-and-bound based exact solution method with Lagrangian relaxation boundin...

In the past decade, major airlines in the U.S. have moved from banked hub-and-spoke operations to de-banked hub-and-spoke operations to lower operating costs. In [1], it is shown that dynamic airline scheduling, an approach that makes minor adjustments to flight schedules in the booking period by re-fleeting and re-timing flight legs, can significantly improve utilization of capacity and hence ...

Objective: To compare the return-on-investment (ROI) of an integrated practice model versus a "hub and spoke" practice model of pharmacist provided medication therapy management (MTM). Methods: A cohort retrospective analysis of MTM claims billed in 76 pharmacies in North Carolina in the 2010 “hub and spoke” practice model and the 2012 “integrated” practice model were analyzed to calculate the ...

This paper deals with hub-and-spoke network design in the liner shipping sector. It introduces a capacitated directed cycle hub location and cargo routing problem under congestion. The involves four decisions: of ports; allocation non-hub ports to construction cyclic route at port level; between all origin-destination demand pairs network. objective is minimize cost which includes fixed opening...

20 21 Coordinated variation among positions in amino acid sequence alignments can reveal genetic 22 dependencies at non-contiguous positions, but methods to assess these interactions are 23 incompletely developed. Previously, we found genome-wide networks of covarying residue 24 positions in the hepatitis C virus genome (Aurora et al., Journal of Clinical Investigation 2009 25 119:225). Here, w...

With BGP/MPLS Virtual Private Networks (VPNs), providing any-to-any connectivity among sites of a given VPN would require each Provider Edge (PE) router connected to one or more of these sites to hold all the routes of that VPN. The approach described in this document allows the VPN service provider to reduce the number of PE routers that have to maintain all these routes by requiring only a su...

In this paper, a complete review of published researches about hierarchical facility location and hub network problems is presented. Hierarchical network is a system where facilities with different service levels interact in a top-down way or vice versa. In Hierarchical systems, service levels are composed of different facilities. Published papers from (1970) to (2015) have been studied and a c...

hub covering location problem, network design,   single machine scheduling, genetic algorithm,   shuffled frog leaping algorithm   hub location problems (hlp) are synthetic optimization problems that appears in telecommunication and transportation networks where nodes send and receive commodities (i.e., data transmissions, passengers transportation, express packages, postal deliveries, etc.) th...

Delta Air Lines is the first and only airline to carry over 100 million passengers in a year, carrying over 105,000,000 passengers in 1998. To provide service to this number of passengers, Delta operates a “hub and spoke” flight system. In the hub and spoke system, certain key airports, or hubs, are designated as the origination point of a large number of flights, thereby allowing a passenger d...