Elevations in plasma serotonin (5-HT) have been implicated in the pathogenesis of cardiac and pulmonary disease. Normally, plasma 5-HT concentrations are kept low by transporter-mediated uptake of 5-HT into platelets and by metabolism to 5-hydroxyindoleacetic acid (5-HIAA). Many abused drugs (e.g., substituted amphetamines) and prescribed medications (e.g., fluoxetine) target 5-HT transporters ...

The hypothesis that serotonin (5-HT)-stimulated phosphoinositide hydrolysis is mediated by the 5-HT-2 binding site in cerebral cortex was tested by comparing antagonist Kd values determined by Schild analyses with Ki values at the 5-HT-2 binding site. A significant correlation was found between Kd values and Ki values at competing for 3H-ketanserin binding (R = 0.98), suggesting that the phosph...

OBJECTIVE A national survey was conducted to determine the extent of use of compounded hormone therapy (C-HT) and to characterize the differences between C-HT users and users of hormone therapy approved by the US Food and Drug Administration (FDA-HT users). METHODS This Internet survey enrolled 3,725 women aged 40 to 84 years who were postmenopausal or experiencing the menopause transition. T...

The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade. Most studies have focused on the fact that L-DOPA can be transformed into dopamine (DA) and released from 5-HT terminals, which is especially important for the management of L-DOPA-induced dysk...

We hypothesized that the 5-hydroxytryptamine (5-HT; serotonin) system is present and functional in veins. In vena cava (VC), the presence of the 5-HT synthesis rate-limiting enzyme tryptophan hydroxylase-1 mRNA and accumulation of the 5-HT synthesis intermediate 5-hydroxytryptophan after incubation with tryptophan supported the ability of veins to synthesize 5-HT. The presence of 5-HT and its m...

Co doping increases the ZnO resistivity ( ρ ) at high T (HT), whereas it has an opposite effect low (LT). H balances effects by neutralizing increase HT and strengthening its decrease LT.

By introducing Pt atoms into the surface of reduced hydrotalcite (HT)-derived nickel (Ni/HT) catalysts by redox reaction, we synthesized an enhanced active and stable Ni-based catalyst for methane ...

The aim of this work was to study the effect a high fat and carbohydrate diet (HFCD) quercetin supplementation on levels dopamine (DA), serotonin (5-HT) their metabolites in Wistar, DA transporter knockout (DAT-KO) obese Zucker fa/fa rats. Animals received control or HFCD for 62 days. Wistar rats quercetin. contents DA, 5-HT, norepinephrine (NE), dioxyphenyl acetate (DOPAC), homovanillic acid (...

Photonic integrated circuits have been designed, simulated, and tested on TriPleX™ platform technology for implementing optical Haar Transform (HT) in the visible spectrum. Optical contain new building block (BB), designed using multimode interference (MMI) structure, performing HT a pair of signals. The Outputs BB demonstrate sum subtraction input signals according to operation. 1st-order 2nd-...

OBJECTIVE We sought to understand the relationship among components of residency education about hormone therapy (HT), knowledge about HT, and provider attitudes toward HT during a time of rapidly changing practice guidelines. METHODS We surveyed residents in the University of Pittsburgh Internal Medicine residency programs between February to April 2002 (after the release of the Heart Estrog...