نتایج جستجو برای: hsa denaturation

تعداد نتایج: 10128  

Journal: :The British journal of nutrition 2017
Mark J McCann Kunjana Rotjanapun John E Hesketh Nicole C Roy

Se is an essential micronutrient for human health, and fluctuations in Se levels and the potential cellular dysfunction associated with it may increase the risk for disease. Although Se has been shown to influence several biological pathways important in health, little is known about the effect of Se on the expression of microRNA (miRNA) molecules regulating these pathways. To explore the poten...

2014
Keisuke Kitamura Shigehiko Takegami Rumi Tanaka Ahmed Ahmed Omran Tatsuya Kitade

Human serum albumin (HSA) in the blood binds long-chain fatty acids (LCFAs), and the number of bound LCFAs varies from 1 to 7 depending on the physical condition of the body. In this study, the influence of LCFA-HSA binding on drug-HSA binding was studied using triflupromazine (TFZ), a psychotropic phenothiazine drug, in a buffer (0.1 M NaCl, pH 7.40, 37°C) by a second-derivative spectrophotome...

2015
Ana Virgínia Van Den Berg Leandro Magalhães Amanda Ferreira Vidal Aline Maria Pereira Ândrea Ribeiro-dos-Santos

Hodgkin Lymphoma (HL) is a neoplasia characterized by the restrict number of malignant cells present in the lymph node. Actual criteria in diagnostic standards don’t consider genetic and epigenetic alterations as risk factors in the development of this disease or in the response of the treatment. MicroRNAs (miRNAs) are important regulatory elements of genic expression that can be altered in the...

2014
Lin Wang Miao-Jun Zhu Ai-Min Ren Hong-Fei Wu Wu-Mei Han Ruo-Ying Tan Rui-Qin Tu

Epithelial ovarian cancer (EOC) is the most common gynecologic malignancy. To identify the micro-ribonucleic acids (miRNAs) expression profile in EOC tissues that may serve as a novel diagnostic biomarker for EOC detection, the expression of 1722 miRNAs from 15 normal ovarian tissue samples and 48 ovarian cancer samples was profiled by using a quantitative real-time polymerase chain reaction (q...

2015
Ivan Igaz Gábor Nyírő Zoltán Nagy Henriett Butz Zsolt Nagy Pál Perge Peter Sahin Miklós Tóth Károly Rácz Peter Igaz Attila Patócs

Purpose. The interaction of hormones of the pituitary-adrenal axis and adrenal cortex-associated circulating microRNAs is mostly unknown. We have studied the effects of dexamethasone and adrenocorticotropin on the expression of five circulating microRNAs (hsa-miR-27a, hsa-miR-200b, hsa-miR-214, hsa-miR-483-5p, and hsa-miR-503) reported to be related to the adrenal cortex in plasma samples. Meth...

2016
Rui Dong Zhen Shen Chao Zheng Gong Chen Shan Zheng

This study aimed to investigate pathogenesis and novel diagnostic biomarkers of biliary atresia (BA). Serum samples from infants with BA and non-BA neonatal cholestasis (NC) were collected for miRNA microarray analysis, and then differentially expressed miRNAs were screened. Differentially expressed miRNAs were validated by qRT-PCR using an independent serum samples from infants with BA and NC....

2013
Yu Ishima Ulrich Kragh-Hansen Toru Maruyama Masaki Otagiri

Nitric oxide (NO) is a ubiquitous molecule involved in multiple cellular functions. Inappropriate production of NO may lead to disease states. To date, pharmacologically active compounds that release NO within the body, such as organic nitrates, have been used as therapeutic agents, but their efficacy is significantly limited by unwanted side effects. Therefore, novel NO donors with better phar...

Journal: :Bioscience trends 2012
Ting Zhao Yang Yang Aizhen Zong Haining Tan Xinlei Song Shuo Meng Chunxia Song Guangli Pang Fengshan Wang

Human serum albumin (HSA) is used as an important plasma volume expander in clinical practice. In the present study, HSA was N-terminally PEGylated and a PEGylated HAS (PEG-HSA) carrying one chain of PEG (20 kDa) per HSA molecule was obtained. The purity, secondary structure and hydrodynamic radius of the modified protein were characterized using sodium dodecyl sulfate polyacrylamide gel electr...

2015
Jonathan Montomoli Rune Erichsen Sussie Antonsen Tove Nilsson Henrik Toft Sørensen

OBJECTIVE Surgery is the only potentially curable treatment for colorectal cancer (CRC), but it is hampered by high mortality. Human serum albumin (HSA) below 35 g/L is associated with poor overall prognosis in patients with CRC, but evidence regarding the impact on postoperative mortality is sparse. METHODS We performed a population-based cohort study including patients undergoing CRC surger...

Journal: :Current Metabolomics 2013
Jeanethe A Anguizola Sara B G Basiaga David S Hage

The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an increase in the amount of non-enzymatic glycation that occurs for serum proteins. One protein that is affected by this process is the main serum protein, human serum albumin (HSA), which is also an important carrier agent for many drugs and fatty acids in the circulatory system. Sulfonylureas drug...

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