Thyrotropin releasing hormone (TRH) is primarily known as the central regulator of the hypothalamic-pituitary-thyroid (HPT) axis. However, TRH also exerts a variety of central nervous system effects independent from its activity in the HPT axis. With advancing age, decreases in TRH synthesis, expression, and activity have been demonstrated. Associated with this emerging evidence suggests that T...

Disks of commercial Al-1050 and ZK60A alloys were stacked together and then processed by conventional high-pressure torsion (HPT) through 1 and 5 turns at room temperature to investigate the synthesis of an Al–Mg alloy system. Measurements of microhardness and observations of the microstructures and local compositions after processing through 5 turns revealed the formation of an ultrafine multi...

Brown tumor of hyperparathyroidism (BTHPT) is rare in the United States and not frequently seen in clinical practice. This is likely because early diagnosis and prompt treatment of this disease process prevent the progression and development of BTHPT. Conversely, BTHPT is more common in underdeveloped countries where fewer patients have access to health care and hyperparathyroidism (HPT) goes u...

The evolutions of microstructure and texture the corrosion behaviour low light rare-earth containing Mg-1.4Nd heavy Mg-0.6Gd Mg-0.4Dy (wt.%) were evaluated compared after processing by high-pressure torsion (HPT) isochronal annealing at 250 450 °C for 1 h using electron backscatter diffraction (EBSD) electrochemical tests in a 3.5% NaCl solution. EBSD results show that dynamic recrystallisation...

Abstract. Ti-6Al-7Nb alloy was quenched below and above the β-phase field processed by high-pressure torsion (HPT) to produce different grain sizes in ultra-fine range. The influence of temperature strain rate over superplastic properties, activation energy sensitivity were evaluated high tensile tests. mechanical properties complemented with Vickers microhardness measurement heat treated HPT-p...

Hexose phosphate is an important carbon source within the cytoplasm of host cells. Bacterial pathogens that invade, survive, and multiply within various host epithelial cells exploit hexose phosphates from the host cytoplasm through the hexose phosphate transport (HPT) system to gain energy and synthesize cellular components. In Escherichia coli, the HPT system consists of a two-component regul...

The hypothalamic-pituitary-thyroid (HPT) axis is a major contributor in maintaining energy expenditure and body weight, and the adipocyte hormone leptin regulates this axis by increasing TRH levels in the fed state. Leptin stimulates TRH directly in the hypothalamic paraventricular nucleus (PVN; direct pathway) and indirectly by regulating proopiomelnocortin neurons in the hypothalamic arcuate ...

BACKGROUND Antibiotic/ herbicide resistant marker genes have been proven to be very useful in plant transformation for the initial selection of desired transgenic events. However, presence of these genes in the genetically modified crops may render the crop less acceptable to the consumers. Among several different approaches, the effectiveness of Cre/lox mediated recombination strategy for sele...

The use of C-terminal parathyroid (C-PTH) assays, performed at a commercial laboratory, was evaluated for one year at Charity Hospital, New Orleans. Of 72 patients, the most frequent diagnosis was primary hyperparathyroidism (1 degree HPT) (n = 17, 24 percent), followed by malignancy (n = 15, 21 percent), chronic renal disease (n = 10, 14 percent), and thiazide diuretics (n = 5, 7 percent). In ...

Primary hyperparathyroidism (HPT) is diagnosed in approximately 100,000 patients in the US each year, with a 2-3:1 female-to-male distribution. In most cases, occurrence is sporadic rather than familial, and 80% to 85% of cases of sporadic primary HPT are caused by a solitary parathyroid adenoma. The diagnosis is made by hypercalcemia with an inappropriately elevated parathyroid hormone (PTH) l...