نتایج جستجو برای: hplc assay

تعداد نتایج: 250926  

Journal: :Central European Journal of Energetic Materials 2016

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2005
Annalise Di Marco Isabella Marcucci Ashok Chaudhary Marina Taliani Ralph Laufer

A rapid and sensitive radiometric assay for assessing the potential of drugs to inhibit cytochrome P450 (P450) 2C9 in human liver microsomes is described. In contrast to the conventional diclofenac 4'-hydroxylation assay, the new method does not require high performance liquid chromatography (HPLC) separation and mass spectrometry. The assay is based on the release of tritium as tritiated water...

Journal: :Europan journal of science and technology 2022

The aim of this study is to determine the amount total aflatoxins and aflatoxin B1 (AFB1) in tomato pepper pastes sold farmer’s markets Istanbul evaluate whether levels were within standards regarded as safe (<5 µg kg-1). For purpose, a 64 samples, including 26 pastes, 15 paprika 23 chili analysed using two different detection methods, enzyme-linked immunoabsorbent assay (ELISA) high-performanc...

2014
Dorcas Osei-Safo Amegnona Agbonon Daniel Yeboah Konadu Jerry Joe Ebow Kingsley Harrison Mamadou Edoh Andrew Gordon Messanvi Gbeassor Ivan Addae-Mensah

This study, conducted as part of our overall goal of regular pharmacovigilance of antimalarial medicines, reports on the quality of 132 artemisinin-based antimalarial medicines distributed in Ghana and Togo. Three methods were employed in the quality evaluation-basic (colorimetric) tests for establishing the identity of the requisite active pharmaceutical ingredients (APIs), semi-quantitative T...

2015
MT. Nguyen NT. Tran M. Vincent A. Capron M. Mourad P. Wallemacq Viet Nam

Mycophenolic acid (MPA) is a potent, selective and uncompetitive inhibitor of the inosine 5’ -monophophate dehydrogenase (IMPDH), which is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides being required during T and B lymphocyte proliferation. In this study, HPLC method was developed and validated to determine the IMPDH activity in human peripheral blood mononuclear ce...

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