The distribution of isotopically labeled hematoporphyrin derivative (HPD) has been studied in mice bearing the spontaneous mammary tumor (fast growing). In stomach, liver, spleen, and pancreas, 3 hr after i.p. injection of [3H]HPD, grains were uniformly distributed over the tissue sections. After 24 hr, the grain density overlying parenchymous areas of these tissues was lower than that over the...

Stinging nettle (Urtica dioica) is a plant well known in traditional medicine for its many beneficial properties, but the lack of standardization regarding product to offer consumers limits diffusion. To this end, drying appears be useful technique low-cost that can stored long time, different procedures may give rise end-products very quality as nutraceutical and antioxidant compounds. Nettle ...

The tumor-localizing photosensitizer hematoporphyrin derivative (HPD) is shown to undergo a simultaneous two-photon excitation into the near-ultraviolet Soret band system upon intense laser irradiation at 750 nm, a spectral region where there is no significant HPD one-photon absorbance in aqueous solution. Subsequent to this excitation, internal conversion and vibrational relaxation occur, resu...

Interspecific hybridization between closely related mammalian species, including various species of the genus Mus, is commonly associated with abnormal growth of the placenta and hybrid foetuses, a phenomenon known as hybrid placental dysplasia (HPD). The role of HPD in speciation is anticipated but still poorly understood. Here, we studied placental and foetal growth in F1 crosses between four...

Photodynamic therapy, which consists of treatment with hematoporphyrin derivative (HPD) followed by photoradiation with visible light, is a promising approach to treatment of various cancers. To gain further understanding of the mechanisms whereby this therapy produces cytotoxicity, we undertook a study of the mitochondrial proton-translocating adenosine triphosphatase, an enzyme performing the...

BACKGROUND Some studies have shown that protein-enriched diets can lead to greater weight loss and improvements in biomarkers of metabolic syndrome (MeS) than standard protein diets. Therefore, the aim of this study was to determine the effect of increased protein intake on weight loss in Mexican adults with MeS. METHODS Randomized controlled trial in 118 adults aged 47.4 ± 11.5 years and mee...

Bayesian highest posterior density (HPD) intervals can be estimated directly from simultions via empirical shortest intervals. Unfortunately, these can be noisy (that is, have a high Monte Carlo error). In this paper, we propose an optimal weighting strategy using quadratic programming to obtain a more computationally stable HPD, or in general, shortest probability interval (Spin). We prove the...