In sampling based hotspot detection, performance engineers sample the running program periodically and record the Instruction Pointer (IP) addresses at the sampling. Empirically, frequently sampled IP addresses are regarded as the hotspot of the program. The question of how well the sampled hotspot IP addresses match the real hotspot of the program is seldom studied by the researchers. In this ...

There is growing evidence that in a variety of organisms the majority of meiotic recombination events occur at a relatively small fraction of loci, known as recombination hotspots. If hotspot activity results from the DNA sequence at or near the hotspot itself (in cis), these hotspots are expected to be rapidly lost due to biased gene conversion, unless there is strong selection in favor of the...

In China, approximately 30,000 babies are born with hearing impairment each year. However, the molecular factors causing congenital hearing impairment in the Xiamen area of Fujian province have not been evaluated. To provide accurate genetic testing and counseling in the Xiamen area, we investigated the molecular etiology of non-syndromic deafness in a deaf population from Xiamen. Unrelated stu...

BACKGROUND Although colorectal cancer death rates in the United States have declined by half since 1970, large geographic disparities persist. Spatial identification of high-risk areas can facilitate targeted screening interventions to close this gap. METHODS We used the Getis-Ord Gi* statistic within ArcGIS to identify contemporary colorectal cancer "hotspots" (spatial clusters of counties w...

This thesis presents methods, techniques and tools for developing three-dimensional representations of tactical intelligence assessments. Techniques from GIScience are combined with crime mapping methods. The range of methods applied in this study provides spatiotemporal GIS analysis as well as 3D geovisualisation and GIS programming. The work presents methods to enhance digital three-dimension...

In visible light communication (VLC), light emitting diodes (LEDs) are used as transmitters; the air is the transmission medium and the photodiodes are used for receivers. This is often referred to as light fidelity (Li-Fi). In this thesis, we provide the methodology to evaluate the performance of VLC hotspot networks in the context of data downloading on the move scenarios by using throughput-...

This article outlines a research program for an anthropology of viral hemorrhagic fevers (collectively known as VHFs). It begins by reviewing the social science literature on Ebola, Marburg, and Lassa fevers and charting areas for future ethnographic attention. We theoretically elaborate the hotspot as a way of integrating analysis of the two routes of VHF infection: from animal reservoirs to h...

The rapid growth of population in urban areas is jeopardizing the mobility and air quality worldwide. One of the most notable problems arising is that of traffic congestion which in turn affects air pollution. With the advent of technologies able to sense real-time data about cities, and its public distribution for analysis, we are in place to forecast scenarios valuable to ameliorate and contr...

The contradiction between the long-term persistence of the chromosomal hotspots that initiate meiotic recombination and the self-destructive mechanism by which they act strongly suggests that our understanding of recombination is incomplete. This "hotspot paradox" has been reinforced by the finding that biased gene conversion also removes active hotspots from human sperm. To investigate the req...