Sex hormones and their receptors play a crucial role in human sexual dimorphism have been traditionally associated with hormone-dependent cancers like breast, prostate, endometrial cancer. However, recent research has broadened our understanding by revealing connections other types of cancers, such as lung cancer, where the androgen receptor found to be particularly significant. This review aim...

The hypothalamic-pituitary-gonadal (HPG) axis, important in reproduction and sex hormone-dependent diseases, is regulated by a number of G protein-coupled receptors. The recently "deorphanized" GPR54 receptor activated by the peptide metastin is thought to be the key regulator of the axis, mainly by releasing gonadotropin-releasing hormone (GnRH) from the hypothalamus. The latter decapeptide, t...

The purpose of this review is to provide an up-to-date report on the molecular and physiologic processes involved in the role of thyroid hormone as an epigenetic factor in brain maturation. We summarize the available data on the control of brain gene expression by thyroid hormone, the correlation between gene expression and physiologic effects, and the likely mechanisms of action of thyroid hor...