Integrin-linked kinase 1 (ILK1) is a serine/threonine kinase that plays important roles in a variety of cellular functions including cell survival, migration and angiogenesis. ILK1 is normally expressed in numerous tissues and activated by growth factors, cytokines and hormones. Dysregulation of ILK1 expression or function is found in several hormonal tumors including breast, ovary and prostate...

Each year in the United States about 1 in 20 women experiences an unintended pregnancy. Understanding the impact of consistent, appropriate, and effective contraception on this major health care concern is key to overcoming this societal and economic burden. In addition to available family-planning services, women need ongoing support in choosing and using methods based on her overall life situ...

This was a retrospective review of the use of emergency hormonal contraception at a university-based health centre over a 6 year period. Usage was greater than noted in previous studies. Condom problems, or not using any form of contraception, were the main reasons for requests. Users were significantly more likely to be smokers than the base population.

Women who are regularly cycling exhibit different partner preferences than those who use hormonal contraception. Preliminary evidence appears to suggest that during pregnancy women's partner preferences also diverge from those prevalent while regularly cycling. This is consistent with the general assertion that women's mate preferences are impacted by hormonal variation. During pregnancy, women...

Endometrial cancer is a heterogeneous disease. Type I cancers are hormonally driven, typically present with a low grade at an early stage, and are of endometrioid histology. These cancers are often cured by surgery, and the rate of recurrence is low. Type II cancers are less differentiated, often appear at a later stage, and are of serous, clear cell, or high grade endometrioid histology. The r...

Breast cancer is rare in male patients. Certain predisposing factors, be they genetic (e.g., BRCA2 gene mutations) or hormonal (imbalance between estrogen and androgen levels), have been implicated in male breast cancer pathophysiology. Male-to-female (MtF) transsexualism is a condition that generally involves cross-sex hormone therapy. Anti-androgens and estrogens are used to mimic the female ...

Additional observations will be presented in this report on the development of mammary cancer in mice, especially virgin females, associated with the action of an inherited hormonal influence, termed the inherited hormonal influence. Comparisons will also be made for the genie make-up of the in herited susceptibility versus the inherited hor monal influence. While the role of the hormonal stimu...

Alprazolam belongs in the group of anxiolytics, medicaments used for reducing anxiety. As most other drugs, it can cause various adverse events, including hormonal disturbances and imbalance. Prolactin elevation is one such hormonal adverse event that can lead to galactorrhoea, or abnormal milk discharge from the breast and amenorrhoea. In this case report we will present the case of a female p...