نتایج جستجو برای: homologous recombination
تعداد نتایج: 122212 فیلتر نتایج به سال:
In all cells, genetic recombination is used to repair DNA breaks and, as a result, genetic information is exchanged between homologous DNA molecules. Discontinuities in DNA strands, specifically double-strand DNA breaks and single-strand DNA gaps, attract the enzymes responsible for the initiation of homologous recombination. In wild-type Escherichia coli, two distinct pathways are responsible ...
Homologous recombination is thought to be the molecular mechanism for maintaining telomere length in alternative lengthening of telomeres (ALT) cells. We used a recombination reporter system to show that the frequency of homologous recombination is the same for ALT- and telomerase-positive cells, suggesting that if ALT cells have a recombination defect it specifically involves telomeric sequenc...
Homologous recombination plays essential roles in mitotic DNA double strand break (DSB) repair and meiotic genetic recombination. In eukaryotes, RAD51 promotes the central homologous-pairing step during homologous recombination, but is not sufficient to overcome the reaction barrier imposed by nucleosomes. RAD54, a member of the ATP-dependent nucleosome remodeling factor family, is required to ...
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