Bisphosphonates are the cornerstone of treatment for osteoporosis. These agents are generally safe and well-tolerated, but concerns have emerged about adverse effects related to long-term use, namely osteonecrosis of the jaw and atypical femur fractures. For most patients at moderate or high risk of fracture, the benefits of treatment far outweigh these serious but rare risks. Bisphosphonates a...

The Green Lady Hostel, Littlehampton (reserved for several months by the C.A.M.W.) was occupied for a fortnight at the end of April by a group of 48 women of very varying ages, in the charge of three members of the C.A.M.W., in addition to the usual household staff of the Hostel. About half the holiday-makers were girls and women placed out under the Guardianship Scheme of the C.A.M.W., while t...

This paper focuses on the neglect of heritage seaside holiday in England. Many towns feature an idiosyncratic architecture dedicated to entertainment and pleasure which, until recently, was rarely considered terms heritage. The examines why this has long been neglected, arguing that – associated with fun among predominantly working-class tourists misaligned conventional ways defining then chang...

TREATMENT of chronic pain in patients with a history of opioid addiction is difficult since tolerance to the opioid agonist effects may require extremely large opioid doses for pain control. Furthermore, insufficient pain control may be hard to discern from craving for more opioids. Although drug-free periods, also called “drug holiday,” can reestablish sensitivity to drugs used to treat Parkin...

I develop a new empirical model for discrete games and apply it to study the release date timing game played by distributors of movies. The results suggest that release dates of movies are too clustered around big holiday weekends and that box office revenues would increase if distributors shifted some holiday releases by one or two weeks. The proposed game structure could be applied more broad...