Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

The interaction of two ruthenium(III) complexes exhibiting high anticancer activity - namely trans-Indazolium(bisindazole) tetrachlororuthenate(III), Hlnd[RuInd(2)Cl(4)], and trans-Imidazolium (bisimidazole) tetrachlororuthenate(III), Hlm[RuIm(2)Cl(4)], - with human serum apotransferrin has been investigated through spectroscopic and chromatographic techniques with the ultimate goal of preparin...

CYP3A4 and CYP3A5 are the most important drug-metabolizing enzymes. For several drugs, heteroactivation of CYP3A-mediated reactions has been demonstrated in vitro. In vivo data suggested a possible acute activation of CYP3A4-catalyzed midazolam metabolism by efavirenz. Therefore, we aimed to investigate the effect of efavirenz on the in vitro metabolism of midazolam. The formation of 1'-hydroxy...

Eslicarbazepine acetate (ESL) is a once-daily novel antiepileptic drug approved in Europe for use as adjunctive therapy for refractory partial-onset seizures with or without secondary generalization. Metabolism of ESL consists primarily of hydrolysis to eslicarbazepine, which is then subject to glucuronidation followed by renal excretion. In this study, we have identified that human liver micro...

Information Systems researchers are often concerned with empirical questions spanning more than one level of analysis. For example, virtual teams research provides a good illustration because such teams are inherently hierarchical entities involving the situated nature of individuals within teams. Despite the importance of multilevel research questions to Information Systems research, the liter...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

The purpose of this paper is to compare the efficiency of Spanish public and publiclysubsidized private high schools by Data Envelopment Analysis (DEA), employing the results provided by a hierarchical linear model (HLM) applied to PISA-2006 (Programme for International Students Assessment) microdata. The study places special emphasis on the estimation of the determinants of school outcomes, th...

Among various HLM techniques, the Multivariate Hierarchical Linear Model (MHLM) is desirable to use, particularly when multivariate criterion variables are collected and the covariance structure has information valuable for data analysis. In order to reflect prior information or to obtain stable results when the sample size and the number of groups are not sufficiently large, the Bayes method h...

According to the Harberger-Laursen-Metzler (HLM) effect an exogenous increase in the terms of trade faced by a small open economy leads to an improvement in that country’s trade balance. In this paper structural vector autoregression techniques are used to investigate whether there is any systematic pattern in the responses of the trade balance to terms of trade shocks for a large number of sma...

Cost performance by NASA programs can generate two stable states within the organization system used for program performance management. These states could be stable individually or show multistability with cusp-like behavior. To test this, we constructed a cusp catastrophe model in a multilevel modeling (HLM) procedure on the cost components of an eleven-month period of one NASA program. HLM w...