Multiple physical variables potentially affect the friction coefficient of Asymmetric Friction Connections (AFC). This paper discusses cyclic response a class AFC subjected to repeated load protocols. Two phenomena are observed. First, coefficient, initially higher due wear and moment-axial force-shear force interaction, stabilizes after multiple cycles. Second, test repetitions on same specime...

BACKGROUND The plasma kallikrein-kinin (K-K) system is activated in acute and chronic relapsing intestinal inflammation induced in Lewis rats by intramural injection of exogenous bacterial components. AIMS To determine whether this effect is model specific, K-K system activation was investigated in a modified indomethacin induced enterocolitis model, as well as bradykinin 2 (B2) receptor dist...

This paper describes friction compensation based control of an industrial pneumatic actuator used for the variable geometry turbocharger (VGT). Adaptive LuGre model for friction has been used in this work. Friction force that is responsible for hysteresis and hunting phenomenon in the position control is compensated with two different control strategies designed to improve low velocity position...

The plasma zymogens factor XI (fXI) and prekallikrein (PK) are activated by factor XIIa (fXIIa) during contact activation. Polyanions such as DNA and RNA may contribute to thrombosis and inflammation partly by enhancing PK and fXI activation. We examined PK and fXI activation in the presence of nucleic acids, and determine the effects of the cofactor high molecular weight kininogen (HK) on the ...

We have recently reported that liposomes in combination with histidine (HK)-containing polymers enhanced the expression of luciferase in transfected cells. In transformed or malignant cell lines, branched HK polymers (combined with liposome carriers) were significantly more effective than the linear HK polymer in stimulating gene expression. In the current study, we found that the linear HK pol...

Expression of the hexokinase (HK) II gene in skeletal muscle is upregulated by electrically stimulated muscle contraction and moderate-intensity exercise. However, the molecular mechanism by which this occurs is unknown. Alterations in intracellular Ca(2+) homeostasis accompany contraction and regulate gene expression in contracting skeletal muscle. Therefore, as a first step in understanding t...

BACKGROUND AND PURPOSE N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide (W-7) is a well-known calmodulin inhibitor used to study calmodulin regulation of intracellular Ca(2+) signalling-related process. Here, we have determined whether W-7 would inhibit human ether gene (hERG or K(v) 11.1) potassium channels, hK(v) 1.5 channels or hK(IR) 2.1 channels expressed in human embryonic kidney (HEK...

It is well known that classical Coulomb dry friction model does not portrays important physical phenomena occurring in the contact between mating surfaces. Moreover, the discontinuity of force at zero velocity has many drawbacks during numerical simulations. In the attempt of exploring alternatives to Coulomb friction model, this paper present the application of the Dahl friction model in a mul...

BACKGROUND Honour killing (HK) is a problem of public health concern but published data on the phenomenon are limited and many cases likely go unrecognized. Our study focuses on the epidemiological patterns of HK of women in Pakistan, where domestic violence is common and HK occurs but is poorly described. METHODS Human Rights Commission of Pakistan (HRCP) systematically collected data on HK ...

In this paper friction induced limit cycles are predicted for a simple motion system of a single motor-driven inertia subjected to friction and a PID-controlled regulator task. The two friction models used, i.e., (i) the dynamic LuGre friction model and (ii) the static Switch friction model, are compared with respect to the so-called hunting phenomenon. Analysis tools originating from the field...