Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. In this study,...

Reactive oxygen and nitrogen species (ROS/RNS) play a crucial role in inflammatory bowel disease (IBD) exacerbating the chronic inflammatory process. Endogenous and diet antioxidants can neutralize these compounds. The apple is widely consumed, with several antioxidant activity compounds. The present study evaluated the effects of concentrated apple extract (CAE) in acetic acid induced colitis....

Background: The effects of electromagnetic field (EMF) on reproductive system have been of critical concern for a long time. It has been shown that the EMF can adversely affect testicular cells and tissue and decrease male fertility. The most important determinants of male fertility are sperm development and motility, which are affected by changes in several factors including lipocalin 2 protei...

Human breast cancer has been characterized by extensive transcriptional heterogeneity, with dominant patterns reflected in the intrinsic subtypes. Mouse models of breast cancer also have heterogeneous transcriptomes and we noted that specific histological subtypes were associated with particular subsets. We hypothesized that unique sets of genes define each tumor histological type across mouse ...

chemical technique. In this study, it appeared that the amount of immunohistochemically detectable RIG-I was related to the severity of the glomerular lesions, such as that of leucocyte exudation into the glomeruli, in the specimens obtained from cases with active lupus nephritis. Two cases, with severe histological changes and a very high histological activity index, showed significantly more ...

introduction: formocresol is widely used in primary teeth pulpotomies; however it is known to have several side effects. the purpose of this study was to assess pulpal changes of primary teeth pulps after pulpotomy with sodium hypochlorite and formocresol. materials and methods: in this randomized clinical trial, 22 teeth were selected. these teeth were randomly divided into 2 groups (formocres...

Breast cancer is one of the most common malignancies in women. This study was conducted to analyze the association between the expressions of eight immunohistochemical (IHC) indices and clinicopathological characteristics in breast cancers (BCs) and investigate the clinical significance. IHC Envision ldpe-g-nvp was used to detect the expression of estrogen receptor (ER), progesterone receptor (...

IntroductionFemoroacetabular impingement (FAI) is a frequent cause of hip pain associated with the degeneration cartilage in joint. However, molecular events linking bone and deformation joint are unclear.ObjectiveUsing gene expression histological analyses cam-type FAI tissues to discover abnormal biological changes chondrocytes that contribute pathophysiology FAI.MethodsFull-thickness specime...