BACKGROUND Hydroxyurea at a relatively low dose is frequently prescribed to induce hemoglobin F production in patients with sickle cell and β-thalassemia diseases because of its good efficacy and safety profiles. However, a potentially fatal gastrointestinal ulceration was recently found and herein reported. CASE PRESENTATION A thirty-seven-year-old man with transfusion dependent hemoglobin E...

Noroviruses (NVs) are important human pathogens that cause acute gastroenteritis. Genetically related animal enteric NVs have also been described, but there is no evidence of interspecies transmission of NVs. In this study we characterized antibody prevalence among domestic pigs by using recombinant capsid antigens of two human NVs (Norwalk and Hawaii) and one swine NV (SW918) that is genetical...

tity, with an autopsy incidence reported to range from 0.02% to 0.12 % [1 ±3]. We recently experienced a case of early duo− denal adenocarcinoma, which we de− scribe here. We report the magnifying en− doscopic findings in relation to the histo− pathological findings. An 80−year−old man underwent upper endoscopy as part of a routine medical evaluation. This revealed a small elevated lesion in th...

INTRODUCTION ECRG4/C2ORF40 is a potential tumor suppressor gene (TSG) recently identified in esophageal carcinoma. Its expression, gene copy number and prognostic value have never been explored in breast cancer. METHODS Using DNA microarray and array-based comparative genomic hybridization (aCGH), we examined ECRG4 mRNA expression and copy number alterations in 353 invasive breast cancer samp...

Histo-blood group A and B antigens are oligosaccharide antigens important in transfusion and transplantation medicine. The final steps in the synthesis of these antigens are catalyzed by glycosyltransferases encoded by the functional alleles at the ABO locus. Humans have 3 major alleles (A, B, and O), whereas pigs are known to have only A and O alleles. This paper reports the molecular genetic ...

UNLABELLED Pelargonium L. genra (Fam. Geraniaceae) includes over 250 species, most of it native to southern Africa. Nowadays, four perennial species are cultivated in Romania as ornamental plants. Our aim was to establish the main characteristics and differences that occur between Pelargonium zonale, P. hispidum, P. grandiflorum, P. peltatum and P. radens. All in all, the quantitative differenc...

The longitudinal anal muscle (LAM) has been described as a vertical layer of muscular tissue interposed between the circular layers of the internal (IAS) and external (EAS) anal sphincters. There is, however, no general agreement in the literature on its composition and attachments. The aim of this study was to investigate the histological structure, attachments, and topography of the LAM in or...

Gastritis is a common disease in dogs. According to studies, about 40% of dogs suffering from vomiting end up with chronic gastritis or those with no digestive symptoms reveal some levels of gastric histo-pathologic lesions. Studies on dogs and cats indicate that the most prevalent form of chronic gastritis is the lymphocytic plasmocytic form associated with lymphoid follicular hyperplasia and ...

In analogy with histo-blood group A antigen, Forssman (Fs) antigen terminates with α3-N-acetylgalactosamine and can be used by pathogens as a host receptor in many mammals. However, primates including humans lack Fs synthase activity and have naturally occurring Fs antibodies in plasma. We investigated individuals with the enigmatic ABO subgroup A(pae) and found them to be homozygous for common...

Organ homeostasis, cellular differentiation, signal relay, and in situ function all depend on the spatial organization of cells in complex tissues. For this reason, comprehensive, high-resolution mapping of cell positioning, phenotypic identity, and functional state in the context of macroscale tissue structure is critical to a deeper understanding of diverse biological processes. Here we repor...