Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver failure (ALF). We discuss the diagnosis of HLH and Kikuchi-Fujimoto (KF) lymphadenitis in the context of pregnancy and ALF. HLH may respond to c...

Kikuchi's disease is an idiopathic self-limiting necrotizing lymphadenitis. Clinically, it mimics tuberculous cervical lymphadenopathy. The disease is diagnosed by histopathologic study. The only specific treatment that has been reported is empiric steroid therapy. We report a case of tuberculosis that was originally thought to be Kikuchi's disease in a 24-year-old man. When the patient's condi...

I read the article entitled “Neck Abscess: An Unusual Clinical Presentation of Immunoglobulin G4-Related Disease” (IgG4-RD) with great interest given our limited knowledge of the entity to date. Review of the article suggests that the patient had necrotizing granulomatous lymphadenitis, for which the most common associated diseases were ruled out. However, one rare cause of such an aggressive a...

Lymphadenopathy can be caused by localized and systemic diseases. While viral and bacterial infections commonly cause lymphadenitis in young adults, tuberculosis (TB) is a common cause for lymphadenopathy in endemic areas. Besides, lymphadenopathy may be a presenting manifestation of malignancy, systemic disorders and some rare diseases. Thus, relevant evaluation and exclusion of commoner cause...

A double antibody sandwich ELISA developed by ID-DLO, Lelystad to detect Corynebacterium pseudotuberculosis infection was used on 329 sheep from four pedigree Suffolk flocks in which clinical cases of caseous lymphadenitis (CLA) had occurred. At subsequent necropsy, typical CLA lesions were seen in 133 sheep, and the diagnosis was confirmed on culture. Lesions were most commonly seen in lungs (...

Caseous lymphadenitis (CLA) in small ruminants has been diagnosed by culture several times in the state of Grenada. In order to understand the prevalence of CLA, serum samples from 541 sheep and 338 goats from Grenada and Carriacou islands were tested for antibodies against the phospholipase antigen of Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis (CLA) using ...