We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-...

The effect of Mg(2+)-ATP on purified acetylcholinesterase (AChE) from electric tissue of Electrophorus electricus (L.) was studied. The enzymatic activities were measured with acetylcholine and acetylthiocholine as substrates. The kinetic parameters Vmax, Km and Hill coefficient (nH), for acetylcholine and acetylthiocholine were modified with Mg(2+)-ATP. It was shown that acetylcholinesterase p...

It is widely assumed that the control coefficient of an enzyme on pathway flux decreases as the concentration of enzyme increases. However, it has been shown [Kholodenko and Brown (1996) Biochem. J. 314, 753-760] that enzymes with sigmoidal kinetics can maintain or even gain control with an increase in enzyme activity or concentration. This has been described as 'paradoxical control'. Here we f...

Mathematics has always been in search for improvement which captures a large area in computer science, Economics, management and so on. Trigonometric functions are among mathematic functions which apply for a large area in improving and to find Maxterm in these functions has always been important because of their wavy state. And there are different methods as how to get their improving status. ...

We present an information theoretic approach for learning a linear dimension reduction transform for object classification. The theoretic guidance of the approach is that the transform should minimize the classification error, which, according to Fano’s optimal classification bound, amounts to maximizing the mutual information between the object class and the transformed feature. We propose a t...

At the Field Experimentation Centre of Department Genetics and Plant Breeding, 20 rice genotypes, including one check variety, were assessed in order to research genetic variability, heritability, progress, correlation, path coefficient for 13 quantitative features. In Kharif 2022, experiment was carried out utilising a Randomised Block Design with three replications. Over NDR 359 (check), BRRI...

Hill MR, Fried I, Koch C. Quantification and classification of neuronal responses in kernel-smoothed peristimulus time histograms. J Neurophysiol 113: 1260–1274, 2015. First published December 4, 2014; doi:10.1152/jn.00595.2014.—Peristimulus time histograms are a widespread form of visualizing neuronal responses. Kernel convolution methods transform these histograms into a smooth, continuous pr...

1 Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2 Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3 UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United S...

Background: The tea plantation in Ri-Bhoi and West Garo hill districts practicing cultivation Meghalaya state; aimed to access the socio-economic factors for production trend area, productivity were highlighted. Methods: present research investigation was carried out during agricultural year 2018-21 with a total of 200 respondents selected by following multi-stage simple random quota sampling t...