despite a quite short early history, computational drug design and discovery methods can now be efficient in reducing costs and speeding up drug developing procedure. melanocortin-4 receptor (mc4r) is a g protein-coupled receptor implicated in the regulation of body weight. despite its clinical reputation, there is a lack of in-depth knowledge about structure and behavior of mc4r in lipid bilay...

conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

background: the number of reported cases, infected with carbepenem resistant acinetobacter baumannii (crab) and multi-drug resistant (mdr) acinetobacter species had gradually increased in most pla general hospital wards from april to june in 2007. objectives: we have described the investigation of an outbreak of crab and mdr acinetobacter in pla general hospital, beijing. the prospective and re...

Abstract This paper is intended to introduce a filtration analysis of sampled maps based on persistent homology, providing new method for reconstructing the underlying maps. The key idea extend definition homology induced correspondences using framework quiver representations. Our given by most direct summands uniquely determine homology. We provide stability theorems this process and show that...