It remains presently unknown whether vascular reactivity is impaired and whether maladaptive cardiac remodeling occurs before the onset of overt obesity and in the absence of hyperlipidemia. Normal female rats were fed a high-fat diet for 8 weeks and were associated with a modest nonsignificant increase of body weight (standard diet, 300 +/- 10, versus high-fat diet, 329 +/- 14 g) and a normal ...

Flynn ER, Alexander BT, Lee J, Hutchens Jr ZM, MaricBilkan C. High-fat/fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life. Am J Physiol Regul Integr Comp Physiol 304: R278–R285, 2013. First published December 19, 2012; doi:10.1152/ajpregu.00433.2012.—Accumulating evidence suggests that both an adverse pr...

42 43 A high fat diet can increase adiposity, leptin secretion, and plasma fatty acid concentration. In 44 hypertension, this scenario may accelerate cardiac hypertrophy and development of heart failure, 45 but could be protective by activating peroxisome proliferator-activated receptors and expression 46 of mitochondrial oxidative enzymes. We assessed the effects of a high-fat diet on the 47 d...

Adipose tissue represents an important source of angiotensinogen (AGT). We investigated the effect of obesity induced by a high-fat diet on the expression of mouse (mAGT) and human AGT (hAGT) genes in liver, kidney, and heart and different adipose depots in normal mice (C57BL/6J), and in transgenic mice expressing the hAGT gene under the control of its own promoter. Mice were fed a high-fat die...

OBJECTIVES To determine whether a weight-maintaining, moderate (50%) high-fat diet is deleterious to insulin sensitivity in healthy premenopausal women. DESIGN/SETTING/PARTICIPANTS 23 African-American and non-Hispanic white, healthy, overweight, and obese premenopausal women recruited in New York City, USA, fed either a eucaloric, 1-week long high-fat (50% of total Kcal from fat) diet or a eu...

To the Editor: My 85-year-old father has been a lifelong smoker, he remains fit and well and writes a blog about the pleasure he gets from smoking and the benefits in terms of weight loss. Another 127 85-year-old lifelong smokers have written to him saying they have also maintained a normal weight throughout their lives; they feel

We investigated the protective effect of carvacrol against high-fat-diet-induced hepatic steatosis in mice and the potential underlying molecular mechanisms. Mice were fed a normal diet, high-fat diet, or carvacrol-supplemented high-fat diet for 10 weeks. Compared to mice fed the high-fat diet, those fed the carvacrol-supplemented diet showed significantly lower hepatic lipid levels and reduced...