Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity that nontransgenic control rabbits. This degree of overexpression was associated with a 6.7-fold increase in the plasma HDL cholesterol concentration in LCAT transgenic rabbits. On a...

We examined the relations of gender and lipoproteins to subclasses of high density lipoproteins (HDLs) in a cross-sectional sample of moderately overweight men (n = 116) and women (n = 78). The absorbance of protein-stained polyacrylamide gradient gels was used as an index of mass concentrations of HDL at intervals of 0.01 nm across the entire HDL particle size range (7.2-12 nm). At least five ...

background: this study was done to test the notion that opium can reduce serum lipids and decrease the risk of ischemic heart disease (ihd) in opium addicts; we made a comparison between the lipid profiles of opium addicts and non-addicts.   methods: in this study, we compared 100 male opium addicts (according to the icd-10 criteria) who had referred to addiction treatment centers with 75 healt...

Low plasma levels of total cholesterol (TC) with or without hypertriglyceridemia have been frequently described in a variety of hematologic disorders in which anemia is a prominent feature.2,3 It is well established that β-thalassemia is associated with changes in plasma lipids and lipoproteins. In β-thalassemia major, low cholesterol levels caused by a significant reduction of both low-density...

OBJECTIVE To test the hypothesis that the progestogen medrogestone has no effect on changes in lipoprotein metabolism evoked by continuous estrogen replacement therapy, paying special attention to high-density lipoproteins (HDL). DESIGN Open multicenter randomized comparative trial. PATIENTS Postmenopausal hysterectomized women aged 49 to 64 years. INTERVENTION Continuous oral treatment w...

This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a dietary supplement (tablet form) providing 1.8 g/day free (non-esterified) plant sterols and stanols versus placebo for 6 weeks as part of a therapeutic lifestyle changes (TLC) diet in 32 men and women with primary hypercholesterolaemia. Mean ± SE baseline (end of a 5-week TLC diet lead-in) lipid conc...

Plasma very low density lipoprotein (VLDL) cholesterol and triglyceride, low density lipoprotein (LDL) cholesterol and triglyceridea, high density lipoprotein (HDL) cholesterol, glucose and insulin response (sums of 1- and 2-hour postload oral glucose levels), body mass index (BMI), and blood pressure were determined in a representative sample (n = 542) of the adult Israeli Jewish population. P...

Phospholipid transfer protein (PLTP) is a member of the lipid transfer/lipopolysaccharide-binding protein family that first attracted attention by virtue of its functions in intravascular lipoprotein metabolism. These include its key role in mediating transfer of phospholipids from very-lowdensity lipoprotein to high-density lipoprotein (HDL) in conjunction with very-low-density lipoprotein lip...

Phospholipid transfer protein (PLTP) is a member of the lipid transfer/lipopolysaccharide-binding protein family that first attracted attention by virtue of its functions in intravascular lipoprotein metabolism. These include its key role in mediating transfer of phospholipids from very-lowdensity lipoprotein to high-density lipoprotein (HDL) in conjunction with very-low-density lipoprotein lip...

Low levels of high-density lipoprotein cholesterol (HDL-C) are currently considered to be a major risk factor for the development of coronary artery disease (CAD). Deficiencies in the HDL metabolic pathway promote atherosclerosis and contribute to CAD. Low HDL-C levels are included in the Framingham 10-year risk assessment for CAD although they are not yet targeted for therapy. Recent clinical ...