نتایج جستجو برای: hey1

تعداد نتایج: 234  

Journal: :Development 2011
So-ichiro Fukada Masahiko Yamaguchi Hiroki Kokubo Ryo Ogawa Akiyoshi Uezumi Tomohiro Yoneda Miroslav M Matev Norio Motohashi Takahito Ito Anna Zolkiewska Randy L Johnson Yumiko Saga Yuko Miyagoe-Suzuki Kazutake Tsujikawa Shin'ichi Takeda Hiroshi Yamamoto

Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. This state is considered to be essential for the maintenance of satellite cells, but their molecular regulation is unknown. We show that Hesr1 (Hey1) and Hesr3 (Heyl)...

2013
Stefan Nagel Stefan Ehrentraut Jürgen Tomasch Hilmar Quentmeier Corinna Meyer Maren Kaufmann Hans G. Drexler Roderick A. F. MacLeod

Homeobox genes encode transcription factors ubiquitously involved in basic developmental processes, deregulation of which promotes cell transformation in multiple cancers including hematopoietic malignancies. In particular, NKL-family homeobox genes TLX1, TLX3 and NKX2-5 are ectopically activated by chromosomal rearrangements in T-cell neoplasias. Here, using transcriptional microarray profilin...

Journal: :Molecular cancer research : MCR 2012
Giovanna Danza Claudia Di Serio Fabiana Rosati Giuseppe Lonetto Niccolò Sturli Doreen Kacer Antonio Pennella Giuseppina Ventimiglia Riccardo Barucci Annamaria Piscazzi Igor Prudovsky Matteo Landriscina Niccolò Marchionni Francesca Tarantini

UNLABELLED Prostate carcinoma is among the most common causes of cancer-related death in men, representing 15% of all male malignancies in developed countries. Neuroendocrine differentiation (NED) has been associated with tumor progression, poor prognosis, and with the androgen-independent status. Currently, no successful therapy exists for advanced, castration-resistant disease. Because hypoxi...

Journal: :Surgery 2017
Sean Golden Xiao-Min Yu Scott Odorico Vansh Jain Ana Marin Shidong Ma Shannon Kenney Herbert Chen

BACKGROUND Epstein-Barr virus is associated with lymphoid and epithelial malignancies and has been reported to infect thyroid cells. The Epstein-Barr virus protein, EBNA2, regulates viral and cellular promoters by binding to RBP-jκ. Similarly, NOTCH1, a tumor suppressor protein in thyroid epithelial cells, competes with EBNA2 for binding to overlapping sites on RBP-jκ. EBNA2 activates a subset ...

2018
Markus Wirth Daniel Jira Armin Ott Guido Piontek Anja Pickhard

The clinical impact of the expression of NOTCH1 signaling components in squamous cell carcinoma of the pharynx and larynx has only been evaluated in subgroups. The aim of this study was therefore to evaluate NOTCH1 expression in head and neck squamous cell cancer (HNSCC) patient tissue and cell lines. We analyzed tissue from 195 HNSCCs and tissue from 30 normal patients for mRNA expression of N...

Journal: :Circulation 2012
Caroline Cheng Remco Haasdijk Dennie Tempel Esther H M van de Kamp Robert Herpers Frank Bos Wijnand K Den Dekker Lau A J Blonden Renate de Jong Petra E Bürgisser Ihsan Chrifi Erik A L Biessen Stefanie Dimmeler Stefan Schulte-Merker Henricus J Duckers

BACKGROUND New vessel formation contributes to organ development during embryogenesis and tissue repair in response to mechanical damage, inflammation, and ischemia in adult organisms. Early angiogenesis includes formation of an excessive primitive network that needs to be reorganized into a secondary vascular network with higher hierarchical structure. Vascular pruning, the removal of aberrant...

2013
Sara Tesfazghi Jacob Eide Ajitha Dammalapati Colin Korlesky Thomas P Wyche Tim S Bugni Herbert Chen Renata Jaskula-Sztul

Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was investigated. Thiocoraline was isolated from a marine bacterium Verrucosispora sp. MTT assay (3-[4, 5-di...

Journal: :International journal of molecular medicine 2013
Fazli Subhan Tae-Deuk Yoon Hee Jung Choi Ikram Muhammad Jieun Lee Changwan Hong Sae-Ock Oh Sun-Yong Baek Bong-Seon Kim Sik Yoon

Thymic epithelial cells (TECs) play a critical role in T-cell development through their intercellular interactions and by producing various soluble proteins, such as growth factors, cytokines and chemokines. In this study, we report a new role for epidermal growth factor-like domain 8 (EGFL8) in the regulation of the survival and proliferation of mouse thymocytes. Mouse recombinant EGFL8 (rEGFL...

Journal: :Hypertension 2006
Hironori Nakagami Namika Nakagawa Yasushi Takeya Katsunobu Kashiwagi Chisato Ishida Shin-ichiro Hayashi Motokuni Aoki Kunio Matsumoto Toshikazu Nakamura Toshio Ogihara Ryuichi Morishita

Embryonic stem (ES) cells are highlighted as promising cell sources for regenerative medicine. Here, we focused on providing the platform that forced ES cells to reproduce the vascular organization process, leading to efficiency and safety evaluation as preclinical testing of biological agents. Murine ES cell-derived embryoid bodies on matrigel, but not collagen or gelatin, could be differentia...

Journal: :Circulation 2011
Steffen Just Ina M Berger Benjamin Meder Johannes Backs Andreas Keller Sabine Marquart Karen Frese Eva Patzel Gerd-Jörg Rauch Hugo A Katus Wolfgang Rottbauer

BACKGROUND The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one of the prerequisites for the development of tissue-engineered heart valves. METHODS AND RESULTS We isolated here a mutation in zebrafish, bungee (bng(jh177)), which selectively perturbs valve formation in the embryonic heart...

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