Hydrogen evolution reaction (HER) catalysts based on noble metals traditionally suffered from high cost, low activity, and poor stability. Metal-free originating heteroatom-doped carbon materials have been proposed to address these problems, in which the doping configurations electronic structures are critical for modulating electrocatalytic activity. Herein, we reported a sequential approach c...

Abstract Carbon–heteroatom (C–X) cross-coupling is a common method for bond-forming reactions in chemistry but the more electronegative heteroatom X is, challenging bond formation becomes. Although reductive elimination from Cu(III) intermediates to form C–X bonds generally facile reaction, oxidative addition of Cu(I) into carbon–(pseudo)halide aryl (pseudo)halides energetically challenging. Th...

Arynes participate in three-component coupling reactions with N, S, P, and Se functionalities to yield 1,2-heteroatom-difunctionalized arenes. Using 2-iodophenyl arylsulfonates as benzyne precursors, we could effectively add magnesiated S-, Se-, and N-nucleophilic components to the strained triple bond. In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) catalyst trap...

In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF3 groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneo...

This review highlights the rapid evolution of the newly-developed class of palladium-catalyzed cross-coupling reactions of organosilicon compounds. A myriad of heteroatom-containing silicon moieties (silyl hydrides, siletanes, silanols, silyl ethers, orthosiliconates, di- and polysiloxanes and pyridylsilanes) undergo mild and stereospecific cross-coupling. The diversity of methods for introduct...

Michael addition is a premier synthetic method for carbon-carbon and carbon-heteroatom bond formation. Using chiral dilithium amides as traceless auxiliaries, we report the direct enantioselective Michael addition of carboxylic acids. A free carboxyl group in the product provides versatility for further functionalization, and the chiral reagent can be readily recovered by extraction with aqueou...