This review is an endeavor to highlight the progress in the inverse-electron-demand hetero-Diels-Alder reactions of 1-oxa-1,3-butadienes in recent years. The huge number of examples of 1-oxadienes cycloadditions found in the literature clearly demonstrates the incessant importance of this transformation in pyran ring synthesis. This type of reaction is today one of the most important methods fo...

Spheroids that are formed from aggregated cells have enhanced biological function compared to individual cells. In particular, hetero-spheroids composed of different types of cells, such as hepatocytes and endothelial cells, express tissue specific functions at a high level, which is advantageous for more precise drug screening and biological research. In this study, we propose rapid formation ...

The direct formation of (hetero)biaryls from readily available (hetero)aryl halides under mild reaction conditions can be efficiently achieved through the Masuda borylation–Suzuki coupling (MBSC) sequence. MBSC sequence catenates Pd-catalyzed borylation and Suzuki into a one-pot process, giving access to diverse symmetrically unsymmetrically substituted scaffolds. (Hetero)biaryls are ubiquitous...

Vibrational circular dichroism (VCD) spectroscopy was applied to study the stereochemical properties of a star-burst type tetranuclear Ru(III) complex, Δ-(or Λ-)[{Δ-(or Λ-)-Ru(III)(acac)(2)(taet)}(3)Ru(III)] (acac = acetylacetonato; taet = tetraacetylethanato). By comparing the VCD spectra of eight diastereomeric enantiomers, it was shown that the spectra reflected the homo- or hetero-chiral na...

Asymmetric allylation of (hetero)aromatic aldehydes by a zinc(II)-allylbutyrolactone species catalyzed by a chiral BINOL-type phosphoric acid gave β-substituted α-methylenebutyrolactones in 68 to >99% ee and 52-91% isolated yield. DFT studies on the intermediate Zn2+-complex - crucial for chiral induction - suggest a six-membered ring intermediate, which allows the phosphoric acid moiety to act...

The novel complex IndðCOÞ3Mo–RuðCOÞ2Cp (1) (Ind 1⁄4 g-indenyl;Cp 1⁄4 g-cyclopentadienyl), as well as other hetero and homo metallic complexes of molybdenum and ruthenium are catalyst precursors in the aerobic oxidation of THF under ambient conditions. Selectivities towards c-butyrolactone of up to 70% are obtained. For the first time in this transformation, propylformate is isolated besides the...

Seeing the big picture: Asymmetric macromolecular complexes that are NMR active in only a subset of their subunits can be prepared, thus decreasing NMR spectral complexity. For the hetero heptameric LSm1-7 and LSm2-8 rings NMR spectra of the individual subunits of the complete complex are obtained, showing a conserved RNA binding site. This LEGO-NMR technique makes large asymmetric complexes ac...

Volcanogenic massive sulphide (VMS) deposits are also known as volcanic-associated, volcanic-hosted, and volcano-sedimentary-hosted massive sulphide deposits. They typically occur as lenses of polymetallic massive sulphide that form at or near the seafloor in submarine volcanic environments. They form from metal-enriched fluids associated with seafloor hydrothermal convection. Their immediate h...