Topical application of 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) significantly inhibited the development of herpetic keratitis in the eyes of rabbits, as determined by both infectivity and Draize scoring parameters. Significant inhibition of the infection was demonstrated with 10% concentrations of Virazole; a 1% solution had a moderate effect, whereas doses of 0.1 and 0.01...

Rabbits vaccinated with lipopolysaccharide endotoxins or with purified protease preparations from Pseudomonas aeruginosa and Serratia marcescens before corneal challenge with the viable bacteria exhibited significantly less corneal damage than rabbits not vaccinated with the bacterial products. However, the rabbits vaccinated with the lipopolysaccharide endotoxin preparations were significantly...

more potent drugs have become available. Arabinoside adenine and trifluorothymidine (TFT) are both effective and relatively nontoxic alternatives widely used in the management of herpetic disease.' Acyclovir (ACV) (9-(2-hydroxyethoxymethyl) guanine)2 and (E)-5(2-bromovinyl)-2' deoxyuridine),3 recently developed antiviral compounds with potent inhibitory activity against herpes simplex DNA polym...

A study of ocular changes in reactions in leprosy was undertaken to assign these changes, their proper place in the wide spectrum of ocular morbidity in leprosy. 76.1% of eyes of Type I reaction and 89.7% of eyes with Type II reaction showed some ocular involvement. Corneal hypoaesthesia, superficial punctate keratitis, a decrease of corneal film break up time (BUT), prominent corneal nerves, p...

A 22-year-old farmer with recurrent corneal erosions and keratoiritis underwent a penetrating keratoplasty. Investigations carried out on the corneal disc revealed an amoebic keratitis, which is considered to be a very rare condition.

Rabbit corneas infected with vaccinia virus were studied by scanning electron microscopy. The earliest detectable lesion consisted of tiny punctate epithelial pits lined by the intact superficial layers of the epithelium. These lesions were presumed produced by the dissolution of the wing cells with inward collapse of the overlying superficial layer. Examination of more advanced and severe lesi...

Three cases of suppurative keratitis caused by Branhamella catarrhalis are described. Each presented as a localised stromal infiltrate in a previously scarred cornea. The condition responded to penicillin G and to gentamicin treatment.

We studied the influence of lgh-linked genes on the development of keratopathy after corneal inoculation with herpes simplex virus (HSV). Using congenic strains of mice, we found that the lgh-1 gene locus, or genes closely linked to it, influence the clinical expression of HSV infection. Mice with the lgh-1e or lgh-1d allotype routinely developed severe keratopathy after HSV corneal inoculation...

AIM The study was designed to evaluate the long term results of intraoperative mitomycin C in patients with one recurrence of pterygium. METHODS In 45 white patients with one recurrence of pterygium the 'bare sclera technique' was performed and a sterile sponge soaked in a 0.2 mg/ml (0.02%) mitomycin C solution was placed intraoperatively on the sclera for 3 minutes. The control group underwe...

Marked inflammation of the cornea (keratitis solaris) is often observed after exposure to strong solar radiation, especially in high altitudes and snow-covered terrain. Using the action spectrum and the solar spectrum, the radiant exposure causing keratitis solaris was calculated for a horizontal surface. The parameters selected were altitude, season, ozone content and albedo. The radiant expos...