coexisting ankylosing spondylitis and hereditary multiple exostoses have rarely been reported (three patients) previously. a 27-year-old man with hereditary multiple exostoses is presented as a fourth report. at the age of 15 years, the patient had multiple exostoses around the knee, ankle and shoulder joints. he was diagnosed with ankylosing spondylitis 3 years ago. the patient’s sister and hi...

background: neonates affected by hereditary spherocytosis may suffer from significant jaundice. this study was conducted on neonates with jaundice hospitalized at the children’s hospital in bandar abbas, south iran, to determine the frequency of hereditary spherocytosis among them. patients and methods: in this cross-sectional study, 814 neonates with jaundice hospitalized at the children’s hos...

chronic kidney disease is one of the most common complication of systemic lupus erythematosus, which if untreated can lead to  the end-stage renal disease (esrd). early diagnosis and adequate treatment of lupus nephritis (ln) is critical to prevent the chronic kidney disease incidence and to reduce the development of esrd. the treatment of ln has changed significantly over the past decade. in p...

The causes of human glomerular nephritis and nephrosis usually have been considered to involve an allergic mechanism. Both diseases occur more commonly in those who have other manifestations of allergy, often members of families with an allergic diathesis. Acute nephritis usually follows infection with certain strains of hemolytic streptococcus, ' with a latent period like that which would be n...

A 48-year-old woman was admitted to our hospital to undergo evaluation for fatigue, severe weight loss, and nephrotic range proteinuria. Light microscopy of a renal biopsy specimen revealed class III (A) lupus nephritis, while immunofluorescence and electron microscopy only showed sparse immune deposits with findings that were not typical of lupus nephritis. Computed tomography revealed a mass ...

was definitely established. This shows the grave prognosis of the condition and the importance of recognizing early in preg¬ nancy an underlying nephritis so that the patient may be given the proper treatment. Dr. Stander regards nephritis complicated by pregnancy as a distinct and separate entity or disease process from eclampsia and preeclampsia. Blood studies, the subse¬ quent history of the...

OBJECTIVE Previous studies have shown that differential DNA methylation is associated with SLE susceptibility. How DNA methylation affects the clinical heterogeneity of SLE has not been fully defined. We conducted this study to identify differentially methylated CpG sites associated with nephritis among women with SLE. METHODS The methylation status of 428 229 CpG sites across the genome was ...

A 46-year-old female patient presenting with acute interstitial nephritis and anterior uveitis was admitted. The renal biopsy disclosed the presence of interstitial nephritis, confirming the clinical diagnosis of tubulointerstitial nephritis and uveitis (TINU) syndrome. Treatment with oral steroids was started, with prompt improvement of symptoms and laboratory abnormalities.