Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder characterized by uncontrolled multisystem angiogenesis with epistaxis, gastrointestinal bleeding, iron-deficiency anemia, and arteriovenous malformations, and is often associated with increased levels of vascular endothelial growth factor (VEGF). Bevacizumab, a VEGF inhibitor, reduces epistaxis, telangiectasias, and iron-deficien...

While mild gastrointestinal bleeding is common in Crohn's disease, massive extremely rare. In this case, we present a patient who presented with lower bleeding. A literature review of such rare presentation disease will be discussed.

Hereditary angioedema is a rare (1:50,000) hereditary chronic disease from the group of primary immunodeficiencies, which manifests in form recurrent skin and mucous membrane edema respiratory tract gastrointestinal tract. Pathogenesis this are associated with an increased risk number cardiovascular pathologies, complexity management choosing optimal treatment methods. This case report demonstr...

a b s t r a c t “addiction” is a multifaceted complicated disorder with many interrelated causes, as well as environmental and genetic features. several hereditary variables that have an effect on these features might work in together to influence vulnerability and the extent of being an addict. molecular re-sequencing of the latest and formerly researched genes holds a crucial place with regar...

Dr. Cates: This man, who was employed as a fireman in an aircraft factory, died from vomiting blood on the 7th December last year. He was a known victim of familial telangiectasia and had had several previous episodes of haemorrhage from the gut which had been very severe. Before he died he developed a fresh disease for which he received a course of nitrogen mustard. In 1930, at the age of 31, ...

LEOPARD syndrome is an autosomal dominant hereditary disease, which is characterized with cutaneous pigmented patches, electrocardiographic changes, ocular hypertelorism, retarded growth, pulmonic stenosis, genital abnormalities and congenital deafness. The gene of this disease have high penetrance but expression is varied and incomplete forms may be seen. We report a 23 year-old woman wi...

Strokes may occur with a large number of genetic disorders. Natowicz and Kelley have reviewed the single gene disorders capable of causing familial haemorrhagic strokes. These may be classified into four groups: a) hereditary disorders affecting clotting factors or platelets; b) hereditary disease producing vascular anomaly; c) hereditary disease causing hypertension and d) miscellaneous group ...