introduction: her2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. the purpose of this study was to determine the salivary levels and tissue expression of her2/neu in patients with head and neck squamous cell carcinoma (hnscc) and their correlation with clinicopathologic parameters.   materials and methods: enzyme-linked immunoso...

Rationale Despite advances in surgery, chemo­ merapy, and radiation, paciems wim solid mmors such as breast, ovarian, or lung cancer may relapse because of residual microscopic disease. The identification ofseveral tumor amigens, such as HER2! neu and p53, and an increased under­ standing of the role rhey play in malig­ nam cransformation, have led to clinical studies evaluaring antigen-specifi...

Trastuzumab, a monoclonal antibody directed at the HER2 receptor, is one of the most impressive targeted drugs developed in the last two decades. Indeed, when given in conjunction with chemotherapy, it improves the survival of women with HER2 positive breast cancer, both in advanced and in early disease. Its optimal duration, however, is poorly defined in both settings with a significant econom...

Objetivo. Analizar las diferencias en la presentación de variables clínico-patológicas, acuerdo con expresión proteica GRB7, tumores HER2 positivos mujeres colombianas cáncer mama invasivo, diagnosticado entre los años 2013 y 2015 el Instituto Nacional Cancerología E.S.E (INC). Métodos. Se incluyeron 158 pacientes diagnóstico confirmado ductal invasivo. evaluó receptores hormonales (receptor es...

Анти-HER2 терапия на основе трастузумаба является стандартом лечения больных HЕR2-позитивными опухолями. Внедрение таргетной терапии позволило кардинально улучшить прогноз и качество жизни HER2-позитивным раком молочной железы (HER2+ РМЖ). В данном клиническом случае представлен первый опыт Иркутской области эффективного препаратом трастузумаб дерукстеканом пациентки с прогрессирующим диссемини...

Background: Breast cancer is the most common female malignancy and the leading cause of cancer mortality in women worldwide. The human epidermal growth factor receptor2 (HER2) is a transmembrane tyrosine kinase receptor that is usually overexpressed in human breast cancers. Stable cell lines heterogeneously overexpressing HER2 are highly required as in vitro models for breast cancer research. T...