Abstract Background The tumor immunological microenvironment (TIME) has a prominent impact on prognosis and immunotherapy. However, the heterogeneous TIME mechanisms by which affects immunotherapy have not been elucidated in hepatocellular carcinoma (HCC). Methods A total of 2195 eligible HCC patients from TCGA GEO database were collected. We comprehensively explored different phenotypes its cl...

Spontaneous rupture of hepatocellular carcinoma (HCC) is a potentially lethal complication. Despite various treatment modalities with curative intent, there are scant data on ruptured cases achieving complete pathological response (pCR), only handful case reports. We report Chinese male patient large advanced HCC (aHCC) first detected in an emergency setting, developing pCR after multidisciplin...

context several risk factors play the role in the development of hepatocellular carcinoma (hcc) from which chronic hepatitis b and c infections are the most important ones. dna integration of hepatitis viruses alters the function of critical genes promoting malignant transformation of virus-infected liver cells. evidence acquisition there are remarkable geographic differences in prevalence of c...

Background: Hepatocellular carcinoma is the most prevalent primary cancer of liver globally and responsible for majority cancer-related fatalities. The purpose research was to establish frequency enhanced cd34 expression in sinusoid-like vascular endothelial cells carcinoma. Methods: CMH Multan's Department Histopathology carried out a cross-sectional study. Histochemical staining performed. Be...

Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These ...

The mitotic spindle checkpoint (SAC) genes have been considered targets of anticancer therapies. Here, we sought to identify the attractive mitotic spindle checkpoint genes appropriate for human hepatocellular carcinoma (HCC) therapies. Through expression profile analysis of 137 selected mitotic spindle checkpoint genes in the publicly available microarray datasets, we showed that 13 genes were...

PURPOSE To investigate the regulatory mechanism of miR-218 in human hepatocellular carcinoma (HCC). METHODS qPCR was used to compare the expression levels miR-218 among six hepatocellular carcinoma cell lines and normal liver tissues. After transfecting MHCC97L cells with either miR-218 mimics or miR-218 inhibitor, western blotting was used to examine the expressing patterns of cyclinD1, p21,...

This study investigated the inhibitory effect and mechanism of curcumol on growth human hepatocellular carcinoma (HCC) HepG2 xenografts in nude mice. Curcumol was isolated from zedoary turmeric oil. The xenograft model mice established. Forty modeled were divided into model, cisplatin, cisplatin+curcumol groups. latter three groups treated with 2 mg/kg 100 cisplatin combined curcumol, respectiv...

Hepatitis C virus (HCV) is one of the leading causes chronic liver disease. Hepatocellular carcinoma (HCC) a major complication associated with HCV infection, significant mortality and morbidity rates. This study aimed to measure biochemical parameters RNA levels for detection severity hepatitis virus- hepatocellular carcinoma. The was conducted on 100 patients, ages ranging from 36 68 years p...

BACKGROUND During the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. However, there is a potential concern for malignant transformation after stem cell therapy. The aim of this study was to evaluate the development of hepatocellular carcinoma (HCC) after autologous bone marrow stem cell transplantation for liver cirrhosis. METHODS All the patien...