A 29-day-old infant was evaluated at our center for a hepatic mass found during gestation. Ultrasound revealed a heterogeneous lesion which comprised three anechoic areas with hypoechoic debris and a predominantly hyperechoic central region with signs of vascularization on Doppler imaging (Figure 1A). Computed tomography showed a large bulging mass with three clearly defined cystic components w...

We and others have described loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene in 70% of Wilms' tumors (WT), an embryonal kidney tumor, and we have also found LOI of the H19 gene in 29% of WTs. In WT, LOI of IGF2 is coupled to down-regulation of H19. LOI of IGF2 has subsequently been described in a second embryonal neoplasm, rhabdomyosarcoma. However, the hypothesis that...

In North America, children with malignant liver tumors have been treated in a cooperative group study since early 1970s. This manuscript describes the results of these studies.

Beckwith-Wiedemann Syndrome (BWS) is associated with early development of embryonal tumours usually in the first four years of life. We describe a patient who presented with a right adrenal cyst in the first month of life and hepatoblastoma in the third month of life. A cavernous haemangioma was subsequently found in the resected tumour.

Entre las neoplasias malignas más frecuentes del mundo, el carcinoma hepatocelular (CHC) es la segunda causa de muerte relacionada con cáncer (1). Su incidencia se ha duplicado durante dos últimas décadas y mayor carga produce en los países ingresos bajos medianos. Los tumores hepáticos primarios malignos suelen describirse como una patología que afecta principalmente a hombres mayores 40 años ...