BACKGROUND AND AIM Liver transplantation is a potential cure for liver damage from Wilson's disease but the course of neuropsychiatric manifestations after transplantation remains undetermined. MATERIAL AND METHODS In this study, data on all patients who'd received a liver transplant for Wilson's disease at the Shiraz Organ Transplantation Center between December 2000 and March 2014 were revi...

In the present study, we assessed the efficiency of four BMSC transplantation methods as a therapy for liver failure. A rat model (80 Sprague-Dawley rats) of D-galactosamine (D-gal)/lipopolysaccharide (LPS)-induced acute liver failure (ALF) was established and the rats were divided into 5 groups: a hepatic artery injection group, a portal vein injection group, a vena caudalis injection group, a...

BACKGROUND & AIMS We applied advanced magnetic resonance imaging and Voxed based Morphometry analysis to assess brain tissue density in patients with cirrhosis. METHODS Forty eight patients with cirrhosis without overt hepatic encephalopathy (17 Child A, 13 Child B, and 18 Child C) and 51 healthy subjects were matched for age and sex. Seventeen patients had history of overt hepatic encephalop...

Hepatic ischemia-reperfusion injury is a phenomenon in which exacerbating damage of liver cells due to restoration blood flow following ischemia during surgery, especially those involving transplantation. Mitochondria, the energy-producing organelles, are crucial for cell survival and apoptosis have evolved range quality control mechanisms maintain homeostasis mitochondrial network response var...

I N THE LAST few years, liver transplantation has been indicated as therapy for patients with acute hepatic failure.! Since liver transplantation represents the last therapeutic option for this entity, it is extremely important to define the timing for the operation based on the evolution of the clinical parameters of the disease. On the basis of studies conducted on an acetaminophen-induced mo...

Survival rates after liver transplantation have increased dramatically over the past 20 years. Cardiovascular disease is most common extra-hepatic cause of mortality in long-term post transplant. This intimately linked with both higher pre-existing metabolic syndrome these patients as well propensity to develop de novo post-transplant. unfavorable profile that contributes cardiovascular multifa...

OBJECTIVE To review the anatomical variations of the right lobe encountered in 40 living liver donors, describe the surgical management of these variations, and summarize the results of these procedures. SUMMARY BACKGROUND DATA Anatomical variability is the rule rather than the exception in liver and biliary surgery. To make effective use of liver segments from living donors for transplantati...

Hepatic tumors often recur in the liver after surgical resection. Postoperative radiotherapy (RT) could improve survival, but curative RT may induce delayed life-threatening radiation-induced liver damage. Because RT inhibits liver regeneration, we hypothesized that unirradiated, transplanted hepatocytes would proliferate preferentially in a partially resected and irradiated liver, providing me...

Numerous causes can lead to hepatic dysfunction following orthotopic liver transplantation. The most common cause is rejection, which is usually nonpreventable. The clinical presentation, time of onset, and even treatment are variable. Other causes, such as perioperative ischemic injury, vascular thrombosis, and complications of bile duct reconstruction may be preventable with good surgical tec...

Autosomal recessive polycystic kidney disease (ARPKD) is a congenital hepatorenal fibrocystic disease. The hepatic manifestations of ARPKD can range from asymptomatic to portal hypertension and massively dilated biliary system that results in liver transplantation. Hepatic complications of ARPKD typically present with signs of portal hypertension (splenomegaly and thrombocytopenia) or cholangit...