In view of the androgen control exerted upon renal gulonolactonase activity in the rat and the absence of such control upon hepatic enzyme activity, the renal enzymes from the adult male and female have been compared with each other as well as with the male hepatic enzyme. The enzymes from the three sources are immunologically alike. Moreover, these enzymes have been characterized with respect ...

Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administra...

When rats adapted to a stock diet were fed on various high-carbohydrate diets, the hepatic activities of glucose-6-phosphate dehydrogenase, malic enzyme and acetyl-CoA carboxylase were more greatly increased by fructose than by any other carbohydrate. Even in the diabetic state, the enzyme activities were somewhat increased by fructose feeding. After feeding on the diets for 9 days, the hepatic...

Background: Breast cancer is a hormone-dependent malignancy that is associated with estrogen and progesterone interactions. The liver is the most important organ to be affected by the metastasis of breast cancer, which causes functional impairment. We compared levels of obesity, 17β-estradiol, and secreted proteins in postmenopausal women with breast cancer but without hepatic symptoms to those...

background bile duct injuries (bdi) during cholecystectomy are now being recognized as major health problems. objectives herein, we present our experience with handling major bdis and report long-term outcome of hepaticojejunostomies followed by trans-jejunal hepatic duct stenting performed to reconstruct extra-hepatic biliary tracts. materials and methods in this case series, we prospectively ...

Immunoelectrophoretic analyses of catalase in a variety of tissues from normal Sprague-Davvley rats were made with rab bit anti-rat hepatic catalase serum. Several distinctive patterns of the enzyme were identified by this means. A pattern previ ously described for purified hepatic catalase with 6 immunologically independent subcomponents was again recognized in one of the chromatographically s...

Hepatic oxidative stress is a major contributor to the pathogenesis of several acute liver diseases. Diagnostic markers of hepatic oxidative stress may facilitate early detection and intervention. Bach1 is an oxidative stress-responsive transcription factor that represses heme oxygenase 1 (HO-1), the rate-limiting enzyme in the catabolism of heme, a potent pro-oxidant. We previously demonstrate...

T HE ENZYME, XANTHINE OXIDASE, is thought to play a central role in the mobilization of storage iron from the liver.1 In the presence of xanthine oxidase, xanthine is oxidized to uric acid, the enzyme acting as electron acceptor in the oxidation reaction . ‘ Coupled to the oxidation of uric acid is the reduction of ferric ferritin to the ferrous state. The livers of immature rats contain very l...