The present report on experimental hepatic injury is based on observations amassed during the last 9 years, comprising 1922 rats. It has been shown that there are several dietary factors which may intervene, singly or in combination, in the development of massive or zonal hepatic necrosis. Deficiency of sulfur-containing amino acids is only one of them. From the present studies, tocopherol emer...

Pseudocirrhosis is a radiologic term that describes the serial development of diffuse hepatic nodularity caused by chemotherapy for hepatic metastasis, especially from breast cancer. It is characterized by morphologic changes mimicking liver cirrhosis following chronic liver diseases, such as multifocal capsular retraction and enlargement of the caudate lobe, and is a potential cause of portal ...

Patients with decompensated hepatic cirrhosis may present systemic alterations and dysfunction of multiple organs. Ascites, portal hypertension, esophageal varices, encephalopathy are common complications arising from cirrhosis. The aim this paper is to report a case patient liver the transjugular intrahepatic portosystemic shunt. Male, elderly, ex-alcoholic, diagnosed cirrhosis, ascites, varic...

Background Liver biopsy is an invasive test used to diagnose chronic liver disease and to assess the degree of hepatic inflammation and fibrosis. In recent years the accuracy of noninvasive tests has increased. The aim of this study was to evaluate whether the hepatic attenuation detected at triphasic MDCT was related to the degree of cirrhosis and allow the prognosis in human patients to be es...

The pathogenesis of hepatic encephalopathy (HE) involves the interaction between two pathophysiological mechanisms: ammonia detoxification and inflammation. The neuropathology of HE is characterised by astrocyte dysfunction and swelling due to ammonia detoxification. The enzyme glutamine synthetase, which is located mainly in astrocytes, protects neurons by absorbing excess ammonia and glutamat...

Differential Regulation of TRPC4 in the vasopressin magnocellular system by water 1 deprivation and hepatic cirrhosis in the rat. 2 Running Head: TRPC4 regulation by water deprivation and hepatic cirrhosis 3 Authors: T. Prashant Nedungadi, J. Thomas Cunningham 4 5 Department of Integrative Physiology, and Cardiovascular Research Institute 6 University of North Texas Health Science Centre at For...

Dietary cirrhosis of the liver was produced in 223 rats, and then therapy of the condition attempted. Administration of lipotropic factors (casein, methionine, choline) was followed not only by reduction of fat infiltration and by regeneration of hepatic parenchyma but, by a reduction of the degree of the fibrosis. In one group of rats, comparison of sections obtained by biopsy, before treatmen...

Aim Despite advances in the management of liver diseases and changes etiology cirrhosis, few studies have updated prognosis cirrhosis. This study aimed to clarify recent cirrhosis identify risk factors for death. Methods In this retrospective observational by Hepatic Disease Network National Hospital Organization Japan, chart reviews were performed follow patients with beginning 2011. We conduc...

The hepatic repair complex in the setting of cirrhosis has received increasing attention, as it implies the regression of cirrhosis, which was traditionally taken to be an irreversible state. In this brief review, the patterns of fibrosis, the existing staging systems for chronic liver disease and the histopathological features of cirrhosis regression are discussed.

The uptake of (125)I albumin microaggregates (U-(125)I-AMA) from portal blood, during a single passage through the hepatic reticuloendothelial system, has been found to be generally decreased in cirrhosis. To investigate if a similar phenomenon occurs for the colloid flowing through the hepatic artery, the U-(125)I-AMA was first calculated in normal dogs after injection of a mixture of (51)Cr r...