The metalloproteome is defined as the set of proteins that have metal-binding capacity by being metalloproteins or having metal-binding sites. A different metalloproteome may exist for each metal. Mass spectrometric characterization of metalloproteomes provides valuable information relating to cellular disposition of metals physiologically and in metal-associated diseases. We examined the Cu an...

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. At the same time, HEP has no coherent strategy for data preservation and re-use. An inter-experimental Study Group on HEP data preservation and long-term analysis was convened at the end of 2008 and held two workshops, at DESY Large data sets accumulated during many y...

To explore the mechanism of microRNA-125a reversing resistance laryngeal cancer stem cells to cisplatin from mitochondrial autophagy. The human carcinoma cell line Hep-2 was purchased Shanghai Bioleaf Biotechnology Co., Ltd. expression messenger RNA in each group analyzed by reverse transcription-polymerase chain reaction. migration and invasion ability evaluated Transwell assay. Cell apoptosis...

To assess the diagnostic utility of glypican-3 (GPC-3) in comparison to Hep Par 1 in the diagnosis of liver tumours, a cross-sectional study involving 66 resected liver tumours were tested for the protein expression of these markers by immunohistochemistry using monoclonal antibodies. Of the 66 cases, 26 (39.4%) were hepatocellular carcinoma (HCC), 4 (6.1%) were intrahepatic cholangiocarcinoma ...

Heparan sulfate proteoglycans is a major component of the cell surface and extracellular matrix and functions as a barrier against cationic molecules and macromolecules. Heparanase is an endoglucuronidase capable of specifically degrading heparan sulfate, and its activity is associated with the metastatic potential of tumor cells. To inhibit human heparanase expression in human cancer cells, we...

BACKGROUND Hepatoerythropoietic porphyria (HEP) is usually a severe form of cutaneous porphyria, characterized biochemically by an increased urinary excretion of polycarboxylated porphyrins. The disease is the result of a profound deficiency (<10% of normal activity) of uroporphyrinogen decarboxylase (UROD) activity. Hepatoerythropoietic porphyria is inherited as an autosomal recessive trait, w...

Reactions of HgX(2) (X = Cl(-), Br(-), l(-)) with the ligand hep-H (hep-H = 2-(2-hydroxyethyl)pyridine) in methanol at 298 K result in 1D-polymeric chains of [(X)Hg(mu-X)(2)(hep-H)](infinity), 1-3, respectively, where hep-H binds to the Hg(ii) ions in a monodentate fashion exclusively with the pyridine nitrogen donor and the suitably ortho-positioned -(CH(2))(2)OH group of hep-H remains pendant...