نتایج جستجو برای: hedgehog
تعداد نتایج: 9491 فیلتر نتایج به سال:
edgehog signaling is an evolutionarily conserved Hpathway that is important for tissue patterning and repair and has been implicated in inflammatory responses for several tissues. However, the gene and cellular targets of the Hedgehog signaling pathway that orchestrate the inflammatory responses are not clearly defined. Hedgehog signaling is mediated by 3 different ligands (sonic hedgehog [Shh]...
The complete mitochondrial genome of a lesser hedgehog tenrec Echinops telfairi was determined in this study. It is an endemic African insectivore that is found specifically in Madagascar. The tenrec's back is covered with hedgehog-like spines. Unlike other spiny mammals, such as spiny mice, spiny rats, spiny dormice and porcupines, lesser hedgehog tenrecs look amazingly like true hedgehogs (Er...
The face is a reflection of our genome. Facial deformities are oftentimes harbingers of an underlying disease states. For example, decreased Hedgehog activity in the developing craniofacial region causes holoprosencephaly and close-set eyes (hypotelorism). We found that excessive Hedgehog activity, caused by truncating the primary cilia on cranial neural crest cells, led to hypertelorism and fr...
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical role in choroid fissure closure, genetic regulation of this pathway remains poorly understood. Here, we show t...
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