Hemidesmosomes (HDs) are multiprotein adhesion complexes that promote attachment of epithelial cells to the basement membrane. The binding of alpha6beta4 to plectin plays a central role in their assembly. We have defined three regions on beta4 that together harbor all the serine and threonine phosphorylation sites and show that three serines (S1356, S1360, and S1364), previously implicated in H...

We have searched for HDS emission in a small number of hot cores. Using observations of H34 2 S, we have derived upper limits to the [HDS]/[H2S] abundance ratio. The upper limits, which are close to 10−3 can be interpreted in two ways, depending on whether grain surface reactions contribute to the formation of H2S. If grains do not dominate, then the H2S observed is formed in hot, post-shocked ...

Although a number of genes related to melanoma development have been identified through candidate gene screening approaches, few studies have attempted to conduct such analyses on a genome-wide scale. Here we use Illumina 317K whole-genome single-nucleotide polymorphism arrays to define a comprehensive allelotype of melanoma based on loss of heterozygosity (LOH) and copy number changes in a pan...

Although a number of genes related to melanoma development have been identified through candidate gene screening approaches, few studies have attempted to conduct such analyses on a genome-wide scale. Here we use Illumina 317K whole-genome single-nucleotide polymorphism arrays to define a comprehensive allelotype of melanoma based on loss of heterozygosity (LOH) and copy number changes in a pan...

Post-spaceflight results and findings from humans and rodents after conditions of bed rest or simulated microgravity indicate maximum exercise performance is significantly compromised. However, the chronic administration of dobutamine (a synthetic adrenomimetic) to humans in relevant experiments improves exercise performance by mechanisms that prevent the decline in peak O2 consumption (VO2peak...

OBJECTIVE To assess the efficacy and safety of terguride, a partial dopamine agonist, in patients with fibromyalgia syndrome (FMS). METHODS In a 12-week, multicenter, double-blind, placebo-controlled, parallel-group study, 99 patients were randomized at a ratio of 2 to 1 to receive terguride or placebo. Over 21 days, the dosage was titrated to a maximum daily dose of 3 mg of terguride or plac...

Nanodispersed MoS2 and CoMoS2 materials containing metastable 1T phase have been prepared by solvothermal technique, characterized with several physico-chemical methods evaluated in the electrocatalytic hydrogen evolution (HER), thiophene hydrodesulfurization (HDS) 1-pentene hydrogenation (HYD) reactions. The role of different factors stabilization has studied. Stability polymorph upon heating ...

To further understand the role of neuro-immunological interactions in the pathogenesis of rheumatoid arthritis (RA), we studied the influence of sympathetic neurotransmitters on cytokine production of T cells in patients with RA. T cells were isolated from peripheral blood of RA patients or healthy donors (HDs), and stimulated via CD3 and CD28. Co-incubation was carried out with epinephrine or ...

Through regulating thyroid physiology, thyrotropin influences the activities of hormones, including thermogenesis and adaptation to ambient thermal challenges. This study aimed at evaluating some endogenous factors (breed, sex, age body mass index; BMI) season on circulating concentration in Red Sokoto Sahel goats. A total 120 goats were sampled, comprising (n = 20) each during peak cold-dry (C...

With the aging of society, the number of elderly with reduced cognitive function has been increasing worldwide. As a test to measure the cognitive function, the Revised Hasegawa's Dementia Scale (HDS-R) has been used in Japan, Korea, and China. Since there was no HDS-R version for Laotians, the questionnaire and manual were developed through the cooperation of Lao and Japanese researchers. Back...