Oculocerebrorenal Lowe syndrome is a rare X-linked disorder characterized by bilateral cataract, mental retardation and renal Fanconi syndrome. The Lowe syndrome protein Ocrl1 is a PIP2 5-phosphatase, primarily localized to the trans-Golgi network (TGN), which 'loss of function' mutations result in PIP2 accumulation in patient's cells. Although PIP2 is involved in many cell functions including ...

Abstract Detecting anomalies in software logs has become a notable concern for engineers and maintainers as they represent execution paths states. This paper propose novel anomaly detection approach based on the Siamese network top of Recurrent Neural Networks(RNN). Accordingly, we introduce training pair generation algorithm to train which reduces generated significantly while maintaining $$F_...

Data analysis has become a challenge in recent years as the volume of data generated difficult to manage, therefore more hardware and software resources are needed store process this huge amount data. Apache Hadoop is free framework, widely used thanks Distributed Files System (HDFS) its ability relate other processing components such MapReduce for data, Spark - in-memory Processing, Drill SQL ...

Distributed storage systems for large clusters typically use replication to provide reliability. Recently, erasure codes have been used to reduce the large storage overhead of threereplicated systems. Reed-Solomon codes are the standard design choice and their high repair cost is often considered an unavoidable price to pay for high storage efficiency and high reliability. This paper shows how ...

With the rapid development of ophthalmic treatment sector, the realtime access to vast amounts of data of patient treatment and image information plays a particularly important role in the aspect of medical imaging storage and management. Nowadays, the cloud platform of distributed storage based on Hadoop is becoming more and more popular in the field of industry; but the Hadoop is for the stor...

BACKGROUND Approximately 90%~99% of ultraviolet A (UVA) ray reaches the Earth's surface. The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS), which results in oxidative stress such as photoproducts, senescence, and cell death. Thus, UVA is considered a primary factor that promotes skin aging. OBJECTIVE Researchers investigated whether pretreatment with feruli...

The storage and access of massive small files are one of the challenges in the design of distributed file system. Hadoop distributed file system (HDFS) is primarily designed for reliable storage and fast access of very big files while it suffers a performance penalty with increasing number of small files. A middleware called Hmfs is proposed in this paper to improve the efficiency of storing an...

Data-intensive distributed file systems are emerging as a key component of large scale Internet services and cloud computing platforms. They are designed from the ground up and are tuned for specific application workloads. Leading examples, such as the Google File System, Hadoop distributed file system (HDFS) and Amazon S3, are defining this new purpose-built paradigm. It is tempting to classif...

Here, we demonstrate the flexibility of peptide-functionalized poly(ethylene glycol) (PEG) hydrogels for modeling tumor progression. The PEG hydrogels were formed using thiol-ene chemistry to incorporate a matrix metalloproteinase-degradable peptide crosslinker (KKCGGPQG↓IWGQGCKK) permissive to proteolytic remodeling and the adhesive CRGDS peptide ligand. Tumor cell function was investigated by...

OBJECTIVE To test the osteo-regenerative potential of adipose tissue-derived stromal cells (ATSCs), an attractive human source for tissue engineering, in a rat model of mandibular defect. Human dermal fibroblasts (HDFs) were used as a differentiated cellular control in the study. DESIGN The ATSCs and HDFs were isolated from human lipoaspirate and skin biopsy specimens, respectively. Cells wer...